Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons
Transient Receptor Potential Vanilloid 1 (TRPV1) is a polymodal, Ca2+-permeable cation
channel crucial to regulation of nociceptor responsiveness. Sensitization of TRPV1 by G …
channel crucial to regulation of nociceptor responsiveness. Sensitization of TRPV1 by G …
The TRPM8 channel forms a complex with the 5-HT1B receptor and phospholipase D that amplifies its reversal of pain hypersensitivity
I Vinuela-Fernandez, L Sun, H Jerina, J Curtis… - …, 2014 - Elsevier
Effective relief from chronic hypersensitive pain states remains an unmet need. Here we
report the discovery that the TRPM8 ion channel, co-operating with the 5-HT 1B receptor (5 …
report the discovery that the TRPM8 ion channel, co-operating with the 5-HT 1B receptor (5 …
Direct inhibition of the cold-activated TRPM8 ion channel by Gαq
X Zhang, S Mak, L Li, A Parra, B Denlinger… - Nature cell …, 2012 - nature.com
Activation of the TRPM8 ion channel in sensory nerve endings produces a sensation of
pleasant coolness. Here we show that inflammatory mediators such as bradykinin and …
pleasant coolness. Here we show that inflammatory mediators such as bradykinin and …
Emerging roles of TRPM6/TRPM7 channel kinase signal transduction complexes
V Chubanov, M Mederos y Schnitzler, J Wäring… - Naunyn-Schmiedeberg's …, 2005 - Springer
Investigations into Drosophila mutants with impaired vision due to mutations in the transient
receptor potential gene (trp) initiated a systematic search for TRP homologs in other species …
receptor potential gene (trp) initiated a systematic search for TRP homologs in other species …
mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G (o)-type GTP-binding protein
HC Moises, KI Rusin, RL Macdonald - Journal of Neuroscience, 1994 - Soc Neuroscience
It has recently been shown that the activation of mu-opioid receptors inhibits several
components of calcium channel current in rat DRG sensory neurons. mu-Opioid receptors …
components of calcium channel current in rat DRG sensory neurons. mu-Opioid receptors …
[HTML][HTML] TRPM5 is a voltage-modulated and Ca2+-activated monovalent selective cation channel
The TRPM subfamily of mammalian TRP channels displays unusually diverse activation
mechanisms and selectivities [1]. One member of this subfamily, TRPM5, functions in taste …
mechanisms and selectivities [1]. One member of this subfamily, TRPM5, functions in taste …
TRPM7 channel is regulated by magnesium nucleotides via its kinase domain
P Demeuse, R Penner, A Fleig - The Journal of general physiology, 2006 - rupress.org
TRPM7 is a Ca2+-and Mg2+-permeable cation channel that also contains a protein kinase
domain. While there is general consensus that the channel is inhibited by free intracellular …
domain. While there is general consensus that the channel is inhibited by free intracellular …
TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation
N Melzer, G Hicking, K Göbel, H Wiendl - 2012 - journals.plos.org
TRPM2, a highly Ca2+-permeable member of the transient receptor potential melastatin-
related (TRPM) family of cation channels, is expressed in cells of the immune system. We …
related (TRPM) family of cation channels, is expressed in cells of the immune system. We …
Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling
SB Boyer, SM Clancy, M Terunuma… - Journal of …, 2009 - Soc Neuroscience
Downregulation of G-protein-coupled receptors (GPCRs) provides an important mechanism
for reducing neurotransmitter signaling during sustained stimulation. Chronic stimulation of …
for reducing neurotransmitter signaling during sustained stimulation. Chronic stimulation of …