Transient receptor potential TRPM3 channels: Pharmacology, signaling, and biological functions
G Thiel, S Rubil, A Lesch, LA Guethlein… - Pharmacological …, 2017 - Elsevier
The transient receptor potential melastatin-3 (TRPM3) channel belongs to the family of
transient receptor potential (TRP) cation channels that are expressed in a variety of tissues …
transient receptor potential (TRP) cation channels that are expressed in a variety of tissues …
Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human, sensory neurons
TD Sheahan, MV Valtcheva, LA McIlvried, MY Pullen… - Eneuro, 2018 - eneuro.org
The use of human tissue to validate putative analgesic targets identified in rodents is a
promising strategy for improving the historically poor translational record of preclinical pain …
promising strategy for improving the historically poor translational record of preclinical pain …
Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function
ZZ Mei, HJ Mao, LH Jiang - American Journal of Physiology …, 2006 - journals.physiology.org
TRPM2 proteins belong to the melastatin-related transient receptor potential or TRPM
subfamily and form Ca2+-permeable cationic channels activated by intracellular adenosine …
subfamily and form Ca2+-permeable cationic channels activated by intracellular adenosine …
Phosphoinositide 3-kinase cascade facilitates μ-opioid desensitization in sensory neurons by altering G-protein-effector interactions
M Tan, M Groszer, AM Tan, A Pandya… - Journal of …, 2003 - Soc Neuroscience
Signaling via G-protein-coupled receptors undergoes desensitization after prolonged
agonist exposure. Here we investigated the role of phosphoinositide 3-kinase (PI3K) and its …
agonist exposure. Here we investigated the role of phosphoinositide 3-kinase (PI3K) and its …
Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function
SM Carlton, J Du, S Zhou - Brain research, 2009 - Elsevier
Transient receptor potential vanilloid 1 (TRPV1) receptors are critical to nociceptive
processing. Understanding how these receptors are modulated gives insight to potential …
processing. Understanding how these receptors are modulated gives insight to potential …
Neurobiology of TRP channels
TLR Emir - 2017 - books.google.com
During the last two decades, there has been an explosion of research pertaining to the
molecular mechanisms that allow for organisms to detect different stimuli that is an essential …
molecular mechanisms that allow for organisms to detect different stimuli that is an essential …
TRP channels
M Gees, G Owsianik, B Nilius… - Comprehensive …, 2011 - Wiley Online Library
TRP channels constitute a large superfamily of cation channel forming proteins, all related to
the gene product of the transient receptor potential (trp) locus in Drosophila. In mammals, 28 …
the gene product of the transient receptor potential (trp) locus in Drosophila. In mammals, 28 …
Four Ca2+ Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate
L Csanády, B Törőcsik - Journal of General Physiology, 2009 - rupress.org
TRPM2 is a tetrameric Ca2+-permeable channel involved in immunocyte respiratory burst
and in postischaemic neuronal death. In whole cells, TRPM2 activity requires intracellular …
and in postischaemic neuronal death. In whole cells, TRPM2 activity requires intracellular …
TRPM8 channel augments T‐cell activation and proliferation
The transient receptor potential melastatin 8 (TRPM8) is an ion channel that has been
widely studied as a cold‐sensitive nociceptor. However, its importance in nonneuronal cells …
widely studied as a cold‐sensitive nociceptor. However, its importance in nonneuronal cells …