Tumor hypoxia is a physiologic barrier to radiotherapy and anti-tumor drug delivery.
Numerous efforts have been made to overcome this barrier and to improve therapeutic …

Tumors are characterized by an inefficient and disorganized vasculature which leads to
tumor regions that are transiently or chronically undersupplied with oxygen (hypoxia) and …

Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …

Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …

Tumor hypoxia influences the outcome of treatment with radiotherapy, chemotherapy and
even surgery, not only for the treatment of large bulky tumors with extensive necrosis, but …

Hypoxia is a characteristic of most solid tumors. This makes hypoxia an obvious target for
cancer therapy. Both in vitro and in vivo studies have identified a range of different …

Tumor hypoxia, a common feature occurring in nearly all human solid tumors is a major
contributing factor for failures of anticancer therapies. Because ionizing radiation depends …

Abstract Hypoxia (oxygen levels below 1–2%) is a common finding in solid tumors. The
development of tumor hypoxia can be viewed as an imbalance between oxygen supply and …

Tumor regions that are transiently or chronically undersupplied with oxygen (hypoxia) and
nutrients, and enriched with acidic waste products, are common due to an abnormal and …

Hypoxia is an important component of the tumor microenvironment and has been the target
of drug discovery efforts for almost half a century. These efforts have evolved from offsetting …