A vast amount of investigation has centered on how the endothelium and smooth muscle
communicate. From this evidence, myoendothelial junctions have emerged as critical …

Within the vasculature, specialized cellular extensions from endothelium (and sometimes
smooth muscle) protrude through the extracellular matrix where they interact with the …

Please cite this paper as: Sandow SL, Senadheera S, Bertrand PP, Murphy TV, Tare M.
Myoendothelial contacts, gap junctions, and microdomains: anatomical links to function …

Heterocellular communication between vascular smooth muscle cells (VSMC) and
endothelial cells (EC) at the myoendothelial junction (MEJ) is a critical part of control of the …

Gap junctions interconnect vascular cells homocellularly, thereby allowing the spread of
signals along the vessel wall, which serve to coordinate vessel behavior. In addition, gap …

Blood vessels are composed of two primary cell types, endothelial cells and smooth muscle
cells, each providing a unique contribution to vessel function. Signaling between these two …

Modulation of vascular cell calcium is critical for the control of vascular tone, blood flow and
pressure. 2. Specialized microdomain signalling sites associated with calcium modulation …

Key points Electrical signalling in blood vessels is important in acute and long‐term flow
regulation. As myoendothelial gap junctions (MEGJs) provide electrical contacts between …

A smooth muscle hyperpolarization is essential for endothelium-dependent hyperpolarizing
factor–mediated dilations. It is debated whether the hyperpolarization is induced by a factor …

Background/Aims: Myoendothelial junctions (MEJs) represent a specialized signaling
domain between vascular smooth muscle cells (VSMC) and endothelial cells (EC). The …