Lack of adverse effects in the F1 offspring maternally exposed to genistein at human intake dose level

KS Kang, JH Che, YS Lee - Food and chemical toxicology, 2002 - Elsevier
Recently there has been growing concern about endocrine disrupters (ED) derived from
synthetic and natural chemicals. It has been argued that ED might cause developmental …

Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality in mice

MR Fielden, SM Samy, KC Chou… - Food and Chemical …, 2003 - Elsevier
The objective of the present study was to determine the long-term reproductive effects of
gestational and lactational exposure (0, 0.1, 0.5, 2.5 and 10 mg/kg/day) to genistein on male …

Altered spermatogenesis, steroidogenesis and suppressed fertility in adult male rats exposed to genistein, a non-steroidal phytoestrogen during embryonic …

R Meena, C Supriya, KP Reddy, PS Reddy - Food and Chemical …, 2017 - Elsevier
This article focuses on the effects of prenatal exposure to genistein on the mother, her
pregnancy and reproductive functions of the male progeny, since these issues have …

Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes

WN Jefferson, CJ Williams - Reproductive toxicology, 2011 - Elsevier
Developmental exposure to estrogenic compounds can disrupt sexual differentiation and
adult reproductive function in many animals including humans. Phytoestrogens (plant …

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of genistein

KK Rozman, J Bhatia, AM Calafat… - … Research Part B …, 2006 - Wiley Online Library
The National Toxicology Program (NTP) and the National Institute of Environmental Health
Sciences (NIEHS) established the NTP Center for the Evaluation of Risks to Human …

Disruption of the developing female reproductive system by phytoestrogens: genistein as an example

WN Jefferson, E Padilla‐Banks… - Molecular nutrition & …, 2007 - Wiley Online Library
Studies in our laboratory have shown that exposure to genistein causes deleterious effects
on the developing female reproductive system. Mice treated neonatally on days 1–5 by …

[HTML][HTML] Reproductive sequelae in female rats after in utero and neonatal exposure to the phytoestrogen genistein

CA Awoniyi, D Roberts, DNR Veeramachaneni… - Fertility and sterility, 1998 - Elsevier
Objective: To determine reproductive sequelae in female rats after in utero and lactational
dietary exposure to genistein. Design: Experimental animal study. Setting: University …

Disruption of the female reproductive system by the phytoestrogen genistein

WN Jefferson, E Padilla-Banks, RR Newbold - Reproductive Toxicology, 2007 - Elsevier
Studies in our laboratory have shown that developmental exposure to genistein causes
deleterious effects on the reproductive system. Oral exposure to genistin (25mg/kg) …

Effects of dietary genistein exposure during development on male and female CD (Sprague-Dawley) rats

KB Delclos, TJ Bucci, LG Lomax, JR Latendresse… - Reproductive …, 2001 - Elsevier
Genistein is a naturally occurring isoflavone that interacts with estrogen receptors and
multiple other molecular targets. Human exposure to genistein is predominantly through …

Reproductive safety studies with genistein in rats

RM McClain, E Wolz, A Davidovich, J Edwards… - Food and chemical …, 2007 - Elsevier
Genistein is a phytoestrogen that occurs naturally in the diet and is found in a wide variety of
plant-derived foods especially in soybeans and soy-based foods. There is wide spread …