Autoimmune AQP4 channelopathies and neuromyelitis optica spectrum disorders

SR Hinson, VA Lennon, SJ Pittock - Handbook of clinical neurology, 2016 - Elsevier
Neuromyelitis optica (NMO) spectrum disorders (SD) represent an evolving group of central
nervous system (CNS)-inflammatory autoimmune demyelinating diseases unified by a …

Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin‐4 channelopathies: a decade later

SJ Pittock, CF Lucchinetti - Annals of the new York Academy of …, 2016 - Wiley Online Library
The discovery of AQP4‐IgG (a pathogenic antibody that targets the astrocytic water channel
aquaporin‐4), as the first sensitive and specific biomarker for any inflammatory central …

Neurological autoimmunity targeting aquaporin-4

SR Hinson, A McKeon, VA Lennon - Neuroscience, 2010 - Elsevier
Neuromyelitis optica (NMO) is the first inflammatory autoimmune demyelinating disease of
the CNS for which a specific tissue target molecule has been identified—the astrocytic water …

Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin‐4 channelopathies

R Iorio, SJ Pittock - Clinical and Experimental …, 2014 - Wiley Online Library
Water channels are a recognized “novel” target for central nervous system, inflammatory,
autoimmune, demyelinating diseases, and represent an evolving spectrum of disorders …

[PDF][PDF] Neuromyelitis optica spectrum disorders with and without aquaporin 4 antibody: Characterization, differential diagnosis, and recent advances

RJ Baranello, JR Avasarala - J Neuro Ther, 2015 - nobleresearch.org
Importance: The term neuromyelitis optica spectrum disorders (NMOSD) currently includes
neuromyelitis optica (NMO) and rare neurological disorders characterized by specific IgG …

Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic strategies

E Carnero Contentti, J Correale - Journal of neuroinflammation, 2021 - Springer
Neuromyelitis optica (NMO) is a chronic inflammatory autoimmune disease of the central
nervous system (CNS) characterized by acute optic neuritis (ON) and transverse myelitis …

Aquaporin-4 autoimmunity

A Zekeridou, VA Lennon - Neuroimmunology & Neuroinflammation, 2015 - AAN Enterprises
Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are
unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water …

Common and rare manifestations of neuromyelitis optica spectrum disorder

D Rosales, I Kister - Current allergy and asthma reports, 2016 - Springer
The discovery of a highly specific biomarker of neuromyelitis optica (NMO)—the anti-
aquaporin-4 (AQP4) antibody—has opened new paths to understanding disease …

Neuromyelitis optica: diagnosis, pathogenesis, and treatment

B Cree - Current neurology and neuroscience reports, 2008 - Springer
Although the co-occurrence of myelitis and optic neuritis that characterizes neuromyelitis
optica (NMO) was recognized over a century ago, distinguishing NMO from multiple …

CNS aquaporin-4 autoimmunity in children

A McKeon, VA Lennon, T Lotze, S Tenenbaum… - Neurology, 2008 - AAN Enterprises
Background: In adult patients, autoantibodies targeting the water channel aquaporin-4
(AQP4) are a biomarker for a spectrum of CNS inflammatory demyelinating disorders with …