Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue

SD Hursting, SM Dunlap - Annals of the New York Academy of …, 2012 - Wiley Online Library
Obesity is an established risk and progression factor for many cancers. In the United States
more than one‐third of adults, and nearly one in five children, are currently obese. Thus, a …

Concise review: the obesity cancer paradigm: exploration of the interactions and crosstalk with adipose stem cells

AL Strong, ME Burow, JM Gimble, BA Bunnell - Stem cells, 2015 - academic.oup.com
With the recognition of obesity as a global health crisis, researchers have devoted greater
effort to defining and understanding the pathophysiological molecular pathways regulating …

Biological mechanisms linking obesity and cancer risk: new perspectives

DL Roberts, C Dive, AG Renehan - Annual review of medicine, 2010 - annualreviews.org
Body mass index, as an approximation of body adiposity, is associated with increased risk of
several common and less common malignancies in a sex-and site-specific manner. These …

[PDF][PDF] Link between obesity and cancer: role of triglyceride/free fatty acid cycling

Y Gong, LJ Dou, J Liang - Eur Rev Med Pharmacol Sci, 2014 - europeanreview.org
Obesity has long been suspected to be a risk factor for cancer. The relationship between
body fat deposition and the pathogenesis of cancer has been the subject of many studies …

Translating mechanism-based strategies to break the obesity− cancer link: a narrative review

LA Smith, CH O'Flanagan, LW Bowers, EH Allott… - Journal of the Academy …, 2018 - Elsevier
Prevalence of obesity, an established risk factor for many cancers, has increased
dramatically over the past 50 years in the United States and across the globe. Relative to …

Circulating adipokines and risk of obesity related cancers: A systematic review and meta-analysis

YS Yoon, AR Kwon, YK Lee, SW Oh - Obesity research & clinical practice, 2019 - Elsevier
Background Obesity can influence on carcinogenesis through alterations in adipokines and
subsequent inflammatory changes. This meta-analysis was aimed to comprehensively …

[PDF][PDF] Body fatness as a cause of cancer: epidemiologic clues to biologic mechanisms

T Byers, RL Sedjo - Endocr Relat Cancer, 2015 - scholar.archive.org
Carrying excess body fat is a leading cause of cancer. Epidemiologic evidence gives strong
clues about the mechanisms that link excess adiposity to risk for several cancer sites. For …

Obesity and cancer: symposium on 'Diet and cancer'

T Pischon, U Nöthlings, H Boeing - Proceedings of the Nutrition …, 2008 - cambridge.org
The prevalence of obesity, defined as a BMI of≥ 30· 0 kg/m2, has increased substantially
over previous decades to about 20% in industrialized countries, and a further increase is …

[HTML][HTML] Obesity, type 2 diabetes, and cancer risk

T Scully, A Ettela, D LeRoith, EJ Gallagher - Frontiers in oncology, 2021 - frontiersin.org
Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …

[HTML][HTML] Obesity and the risk of gastrointestinal cancers

J Karczewski, B Begier-Krasińska, R Staszewski… - Digestive diseases and …, 2019 - Springer
Obesity is a risk factor for all major gastrointestinal cancers. With the rapid increase in the
prevalence of obesity worldwide, this link could lead to an elevated burden of cancers of the …