Transforming growth factor (TGF)-β has been associated with fibrogenesis in clinical studies
and animal models. We previously showed that Smad3 promotes COL1A2 gene activation …

Renal fibrosis is a common characteristic of chronic kidney disease (CKD). Aberrant and
excessive depositions of extracellular matrix (ECM) proteins in both glomeruli and interstitial …

Abstract Angiotensin II (Ang II) is a key mediator of chronic kidney disease, in which
epithelial–mesenchymal transition (EMT) is a critical process mediated by the TGFβ/Smad …

Transforming Growth Factor-beta (TGF-β) is a pro-sclerotic cytokine widely associated with
the development of fibrosis in diabetic nephropathy. Central to the underlying pathology of …

Despite the critical role that TGF-β plays in renal fibrosis, transgenic mice that overexpress
human latent TGF-β1 in the skin exhibit normal renal histology and function even though …

OBJECTIVE Although Smad3 has been considered as a downstream mediator of
transforming growth factor-β (TGF-β) signaling in diabetes complications, the role of Smad7 …

Advanced glycation end-products (AGEs) can induce expression of connective tissue growth
factor (CTGF), which seems to promote the development of diabetic nephropathy, but the …

TGF-β1 is a profibrotic cytokine that plays a central role in the onset and progression of
chronic renal diseases. The activity of TGF-β1 is tightly controlled by multiple mechanisms …

Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and
transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating …

Transforming growth factor (TGF)-β plays a critical role in diabetic nephropathy. To isolate
the contribution of one of the signaling pathways of TGF-β, the Smad3 gene in the mouse …