Background The Prospective Epidemiological Research on Functioning Outcomes Related
to Major Depressive Disorder (PERFORM) study has been initiated to better understand the …

Objective: To provide the first head-to-head test of the predictive validity of 2 resolution
levels included in the current consensus definition of major depressive episode (MDE) …

OBJECTIVE: Predicting treatment outcome at an early stage is clinically relevant. The main
objectives are: to compare rates of remission after acute and continuation phase treatment …

Background: Rates of relapse and predictive relapse factors were studied over more than 4
years in a sample of Spanish outpatients with DSM-III-R criteria for unipolar major …

Major depressive disorder (MDD) is associated with significant functional impairment. This
post-hoc analysis of data from two randomized trials assessed the impact of response status …

BACKGROUND: Delayed onset of efficacy of antidepressants and a high proportion of
depressed patients being poor or non-responders to antidepressants are well known clinical …

Major depressive disorder is often marked by multiple recurrences. Unfortunately, it is
difficult to predict specifically which patients will suffer a recurrence. This study examined …

Not all individuals treated for major depressive disorder (MDD) achieve recovery. This
observational study examined the recovery rates in MDD patients and the patient …

Background Initial improvement in the first weeks of antidepressant (AD) treatment is a
useful early predictor of complete AD response. We performed a meta-analysis of AD …

Background: Although residual symptoms after remission from depression are common and
predict early relapse, little is known about the impact of residual symptoms on longer-term …