Structures of endocrine-disrupting chemicals determine binding to and activation of the estrogen receptor α and androgen receptor
H Tan, X Wang, H Hong, E Benfenati… - Environmental …, 2020 - ACS Publications
Endocrine-disrupting chemicals (EDCs) can interact with nuclear receptors, including
estrogen receptor α (ERα) and androgen receptor (AR), to affect the normal endocrine …
estrogen receptor α (ERα) and androgen receptor (AR), to affect the normal endocrine …
Structures of endocrine-disrupting chemicals correlate with the activation of 12 classic nuclear receptors
Endocrine-disrupting chemicals (EDCs) can inadvertently interact with 12 classic nuclear
receptors (NRs) that disrupt the endocrine system and cause adverse effects. There is no …
receptors (NRs) that disrupt the endocrine system and cause adverse effects. There is no …
Activation of steroid hormone receptors: Shed light on the in silico evaluation of endocrine disrupting chemicals
Q Chen, H Tan, H Yu, W Shi - Science of the total environment, 2018 - Elsevier
Endocrine disrupting chemicals (EDCs) are of great concern given their potential influence
on the endocrine system. In silico methods for the evaluation of EDCs have been widely …
on the endocrine system. In silico methods for the evaluation of EDCs have been widely …
Structure− activity relationships for a large diverse set of natural, synthetic, and environmental estrogens
Understanding structural requirements for a chemical to exhibit estrogen receptor (ER)
binding has been important in various fields. This knowledge has been directly and …
binding has been important in various fields. This knowledge has been directly and …
[HTML][HTML] Structural and functional evidences for the interactions between nuclear hormone receptors and endocrine disruptors at low doses
P Balaguer, V Delfosse… - Comptes …, 2017 - comptes-rendus.academie-sciences …
Résumé Endocrine-disrupting chemicals (EDCs) represent a broad class of exogenous
substances that cause adverse effects in the endocrine system mainly by interacting with …
substances that cause adverse effects in the endocrine system mainly by interacting with …
A structural view of nuclear hormone receptor: endocrine disruptor interactions
A Le Maire, W Bourguet, P Balaguer - Cellular and molecular life sciences, 2010 - Springer
Endocrine-disrupting chemicals (EDCs) represent a broad class of exogenous substances
that cause adverse effects in the endocrine system by interfering with hormone biosynthesis …
that cause adverse effects in the endocrine system by interfering with hormone biosynthesis …
Structural and functional profiling of environmental ligands for estrogen receptors
V Delfosse, M Grimaldi, V Cavaillès… - Environmental …, 2014 - ehp.niehs.nih.gov
Background: Individuals are exposed daily to environmental pollutants that may act as
endocrine-disrupting chemicals (EDCs), causing a range of developmental, reproductive …
endocrine-disrupting chemicals (EDCs), causing a range of developmental, reproductive …
In Silico Identification and Pharmacological Evaluation of Novel Endocrine Disrupting Chemicals That Act via the Ligand-Binding Domain of the Estrogen Receptor α
Endocrine disrupting chemicals (EDCs) pose a significant threat to human health, society,
and the environment. Many EDCs elicit their toxic effects through nuclear hormone …
and the environment. Many EDCs elicit their toxic effects through nuclear hormone …
Endocrine disrupting chemicals targeting estrogen receptor signaling: identification and mechanisms of action
Many endocrine disrupting chemicals (EDCs) adversely impact estrogen signaling by
interacting with two estrogen receptors (ERs): ERα and ERβ. Though the receptors have …
interacting with two estrogen receptors (ERs): ERα and ERβ. Though the receptors have …
Assessment and molecular actions of endocrine‐disrupting chemicals that interfere with estrogen receptor pathways
G Kerdivel, D Habauzit, F Pakdel - International journal of …, 2013 - Wiley Online Library
In all vertebrate species, estrogens play a crucial role in the development, growth, and
function of reproductive and nonreproductive tissues. A large number of natural or synthetic …
function of reproductive and nonreproductive tissues. A large number of natural or synthetic …