More malignant tumors contain more hypoxic regions. In hypoxic tumor cells, expression of a
series of hypoxiaresponsive genes related to malignant phenotype such as angiogenesis …

Hypoxia-inducible factor (HIF) functions as a master transcriptional regulator for adaptation
to hypoxia by inducing adaptive changes in gene expression for regulation of proliferation …

Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant tumor progression
and in the development of resistance to radiotherapy. We designed a novel fusion protein …

Solid tumors containing more hypoxic regions show a more malignant phenotype by
increasing the expression of genes encoding angiogenic and metastatic factors. Hypoxia …

The transcriptional activity of hypoxia-inducible factor-1 (HIF-1) is associated with tumor
malignancies; therefore, it is important to comprehend its dynamism in solid tumors …

The influence of the tumor microenvironment and hypoxia plays a significant role in
determining cancer progression, treatment response, and treatment resistance. That the …

Purpose We aimed to develop a radiolabeled peptide probe for the imaging of hypoxia-
inducible factor-1 (HIF-1)-active tumors. Procedures We synthesized the peptide probes that …

Human solid tumors contain hypoxic regions that have considerably lower oxygen tension
than normal tissues. They are refractory to radiotherapy and anticancer chemotherapy …

Tumor hypoxia plays a crucial role in tumorigenesis. Under hypoxia, hypoxia-inducible
factor 1α (HIF-1α) regulates activation of genes promoting malignant progression. Under …

Abstract Hypoxia-inducible factor-1 (HIF-1) is responsible for various gene expressions
related to tumor malignancy, such as metastasis, invasion and angiogenesis. Therefore …