Increase of bcr-abl chimeric mRNA expression in tumor cells of patients with chronic myeloid leukemia precedes disease progression
A Gaiger, T Henn, E Horth, K Geissler, G Mitterbauer… - 1995 - ashpublications.org
The translocation t (9; 22) in chronic myeloid leukemia (CML) generates a bcr-abl fusion
gene that codes for an aberrant chimeric mRNA. Cell lines established from CML patients in …
gene that codes for an aberrant chimeric mRNA. Cell lines established from CML patients in …
A novel BCR-ABL fusion gene (e6a2) in a patient with Philadelphia chromosome-negative chronic myelogenous leukemia
A Hochhaus, A Reiter, H Skladny, JV Melo, C Sick… - 1996 - ashpublications.org
A novel variant of the chimeric BCR-ABL mRNA transcript was detected in a patient with
Philadelphia chromosome-negative (Ph-) chronic myelogenous leukemia (CML) by …
Philadelphia chromosome-negative (Ph-) chronic myelogenous leukemia (CML) by …
Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript [see comments]
In the majority of Philadelphia (Ph)-positive chronic myeloid leukemia (CML) patients, the c-
abl gene is fused to the bcr gene, resulting in the transcription of an 8.5 kb chimeric bcr-abl …
abl gene is fused to the bcr gene, resulting in the transcription of an 8.5 kb chimeric bcr-abl …
Expression of bcr And bcr-abl Fusion Transcripts in Normal and Leukemic Cells
S Collins, H Coleman, M Groudine - Molecular and cellular biology, 1987 - Taylor & Francis
The translocation of the c-abl oncogene from chromosome 9 to the bcr gene on
chromosome 22 in cases of Philadelphia chromosome-positive chronic myelogenous …
chromosome 22 in cases of Philadelphia chromosome-positive chronic myelogenous …
Expression of p210 and p190 BCR‐ABL due to alternative splicing in chronic myelogenous leukaemia
The hallmark of chronic myelogenous leukaemia (CML) is the presence of the Philadelphia
chromosome and its resultant fusion message, BCR‐ABL, and fusion protein, p210. Patients …
chromosome and its resultant fusion message, BCR‐ABL, and fusion protein, p210. Patients …
Molecular abnormalities of bcr and c-abl in chronic myelogenous leukemia associated with a long chronic phase
O Dreazen, M Berman, RP Gale - 1988 - ashpublications.org
Median duration of the chronic phase of chronic myelogenous leukemia (CML) is 3 years;
less than 20% of patients have a chronic phase greater than 7 years. It is unknown whether …
less than 20% of patients have a chronic phase greater than 7 years. It is unknown whether …
Clinical significance of bcr-abl gene rearrangement detected by polymerase chain reaction after allogeneic bone marrow transplantation in chronic myelogenous …
In chronic myelogenous leukemia (CML), amplification of a segment of bcr-abl messenger
RNA (mRNA) by polymerase chain reaction (PCR) can be used to detect minimal residual …
RNA (mRNA) by polymerase chain reaction (PCR) can be used to detect minimal residual …
Analysis of the clinico-hematological relevance of the breakpoint location within M-BCR in chronic myeloid leukemia
A Bennour, I Ouahchi, B Achour, M Zaier, YB Youssef… - Medical oncology, 2013 - Springer
Abstract The Philadelphia chromosome (Ph) derives from the balanced translocation
between chromosomes 9 and 22. This chromosomal translocation results in the fusion …
between chromosomes 9 and 22. This chromosomal translocation results in the fusion …
Real-time quantification of different types of bcr-abl transcript in chronic myeloid leukemia
M Amabile, B Giannini, N Testoni, V Montefusco… - …, 2001 - haematologica.org
BACKGROUND AND OBJECTIVES: The most common translocation in chronic myeloid
leukemia (CML) t (9; 22)(q34; q22) produces the BCR/ABL fusion gene. We set up and …
leukemia (CML) t (9; 22)(q34; q22) produces the BCR/ABL fusion gene. We set up and …
Detection of minimal residual bcr/abl transcripts by a modified polymerase chain reaction
MS Lee, KS Chang, EJ Freireich, HM Kantarjian… - 1988 - ashpublications.org
Abstract The Philadelphia (Ph1) chromosome in chronic myelogenous leukemia (CML)
involves reciprocal translocation of the bcr gene and the c-abl oncogene. The fused bcr/abl …
involves reciprocal translocation of the bcr gene and the c-abl oncogene. The fused bcr/abl …