Little is known about how pathogenic T cells gain access to the uninflamed brain in multiple
sclerosis and experimental autoimmune encephalomyelitis. A new study reports that …

Interleukin 17–producing T helper cells (T H-17 cells) are important in experimental
autoimmune encephalomyelitis, but their route of entry into the central nervous system …

Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …

To perform their distinct effector functions, pathogen‐specific T cells have to migrate to target
tissue where they recognize antigens and produce cytokines that elicit appropriate types of …

The blood–brain barrier (BBB) and the environment of the central nervous system (CNS)
guard the nervous tissue from peripheral immune cells. In the autoimmune disease multiple …

Immunization with myelin antigens leads to the development of experimental autoimmune
encephalomyelitis, an animal model of multiple sclerosis. The disease can also be induced …

Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of
the CNS. Myelin-specific CD4+ Th lymphocytes are known to play a major role in both MS …

Clonally expanded CD8+ T lymphocytes are present in multiple sclerosis lesions, as well as
in the cerebrospinal fluid of patients with multiple sclerosis. In experimental autoimmune …

Although microglial activation occurs in inflammatory, degenerative and neoplastic central
nervous system (CNS) disorders, its role in pathogenesis is unclear. We studied this …

CCL19 and CCL21 are thought to be critical for experimental autoimmune
encephalomyelitis (EAE) induction, but their precise role is unknown. We examined the role …