Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: implications for the …

S Columba‐Cabezas, BS Elena, AF Aloisi - Brain pathology, 2003 - Wiley Online Library
The simultaneous presence of dendritic, T‐and B‐cells in the central nervous system (CNS)
of mice with experimental autoimmune encephalomyelitis (EAE), a model for multiple …

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

A Mildner, M Mack, H Schmidt, W Brück, M Djukic… - Brain, 2009 - academic.oup.com
The chemokine receptor CCR2 plays a vital role for the induction of autoimmunity in the
central nervous system. However, it remains unclear how the pathogenic response is …

Expression of CCR7 in multiple sclerosis: implications for CNS immunity

P Kivisäkk, DJ Mahad, MK Callahan… - Annals of Neurology …, 2004 - Wiley Online Library
It is unclear how immune cells traffic between the lymphoid compartment and the central
nervous system (CNS), which lacks lymphatic vessels and is shielded by the blood–brain …

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

C Schläger, H Körner, M Krueger, S Vidoli, M Haberl… - Nature, 2016 - nature.com
In multiple sclerosis, brain-reactive T cells invade the central nervous system (CNS) and
induce a self-destructive inflammatory process. T-cell infiltrates are not only found within the …

Licensed in the Lungs

RM Ransohoff - Nature, 2012 - nature.com
Licensed in the lungs | Nature Skip to main content Thank you for visiting nature.com. You are
using a browser version with limited support for CSS. To obtain the best experience, we …

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

A Louveau, J Herz, MN Alme, AF Salvador… - Nature …, 2018 - nature.com
Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the
brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic …

Immune cells may fend off Alzheimer disease

M Britschgi, T Wyss-Coray - Nature medicine, 2007 - nature.com
Immune cells may fend off Alzheimer disease | Nature Medicine Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune …

EE McCandless, M Budde, JR Lees… - The Journal of …, 2009 - journals.aai.org
Multiple sclerosis (MS) is an autoimmune disease of the CNS characterized by disruption of
the blood-brain barrier (BBB). This breach in CNS immune privilege allows undeterred …

The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis

I Lazarevic, S Soldati, JA Mapunda, H Rudolph… - Fluids and Barriers of …, 2023 - Springer
The choroid plexus (ChP) has been suggested as an alternative central nervous system
(CNS) entry site for CCR6+ Th17 cells during the initiation of experimental autoimmune …

Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

A Giladi, LK Wagner, H Li, D Dörr, C Medaglia… - Nature …, 2020 - nature.com
Multiple sclerosis (MS) is characterized by pathological inflammation that results from the
recruitment of lymphoid and myeloid immune cells from the blood into the brain. Due to …