A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza

M Shi, R Zhu, Y Zhang, S Zhang, T Liu, K Li, S Liu… - Metabolic …, 2022 - Elsevier
Phenolic acids and tanshinones are main bioactive compounds produced in Salvia
miltiorrhiza widely used in treatment of cardiovascular diseases, which could be promoted …

[HTML][HTML] Transcription Factor SmWRKY1 Positively Promotes the Biosynthesis of Tanshinones in Salvia miltiorrhiza

W Cao, Y Wang, M Shi, X Hao, W Zhao… - Frontiers in Plant …, 2018 - frontiersin.org
Tanshinones, one group of bioactive diterpenes, were widely used in the treatment of
cardiovascular diseases. WRKYs play important roles in plant metabolism, but their …

[HTML][HTML] Transcriptional Profiles of SmWRKY Family Genes and Their Putative Roles in the Biosynthesis of Tanshinone and Phenolic Acids in Salvia miltiorrhiza

H Yu, W Guo, D Yang, Z Hou, Z Liang - International Journal of Molecular …, 2018 - mdpi.com
Salvia miltiorrhiza Bunge is a Chinese traditional herb for treating cardiovascular and
cerebrovascular diseases, and tanshinones and phenolic acids are the dominated …

ABA-responsive transcription factor bZIP1 is involved in modulating biosynthesis of phenolic acids and tanshinones in Salvia miltiorrhiza

C Deng, M Shi, R Fu, Y Zhang, Q Wang… - Journal of …, 2020 - academic.oup.com
Phenolic acids and tanshinones are major bioactive ingredients in Salvia miltiorrhiza, which
possess pharmacological activities with great market demand. However, transcriptional …

[HTML][HTML] Integrated transcriptomics and proteomics to reveal regulation mechanism and evolution of SmWRKY61 on tanshinone biosynthesis in Salvia miltiorrhiza and …

Y Chen, Y Wang, J Guo, J Yang, X Zhang… - Frontiers in plant …, 2022 - frontiersin.org
Tanshinones found in Salvia species are the main active compounds for the treatment of
cardiovascular and cerebrovascular diseases, but their contents are hugely different in …

Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots

C Deng, X Hao, M Shi, R Fu, Y Wang, Y Zhang, W Zhou… - Plant science, 2019 - Elsevier
Tanshinones are the main bioactive diterpenes in Salvia miltiorrhiza Bunge, are widely used
for treating cardiovascular and cerebrovascular diseases. However, the biosynthetic …

[HTML][HTML] Molecular cloning and expression analysis of WRKY transcription factor genes in Salvia miltiorrhiza

C Li, D Li, F Shao, S Lu - BMC genomics, 2015 - Springer
Background WRKY proteins comprise a large family of transcription factors and play
important regulatory roles in plant development and defense response. The WRKY gene …

CRISPR/Cas9-mediated targeted mutagenesis of bZIP2 in Salvia miltiorrhiza leads to promoted phenolic acid biosynthesis

M Shi, Z Du, Q Hua, G Kai - Industrial Crops and Products, 2021 - Elsevier
Phenolic acids comprise the major bioactive compounds in Salvia miltiorrhiza, which can be
increased by abscisic acid (ABA) elicitation. However, the underlying regulation mechanism …

The SmMYB36-SmERF6/SmERF115 module regulates the biosynthesis of tanshinones and phenolic acids in salvia miltiorrhiza hairy roots

Q Li, X Fang, Y Zhao, R Cao, J Dong… - Horticulture …, 2023 - academic.oup.com
Tanshinone and phenolic acids are the most important active substances of Salvia
miltiorrhiza, and the insight into their transcriptional regulatory mechanisms is an essential …

Jasmonic acid regulates the biosynthesis of medicinal metabolites via the JAZ9-MYB76 complex in Salvia miltiorrhiza

S Liu, X Gao, M Shi, M Sun, K Li, Y Cai… - Horticulture …, 2023 - academic.oup.com
Jasmonic acid (JA) signaling pathway plays an important role in tanshinone and phenolic
acid biosynthesis in Salvia miltiorrhiza. However, the specific regulatory mechanism remains …