Autophagy inhibition has been widely accepted as a promising therapeutic strategy in
cancer, while the lack of effective and specific autophagy inhibitors hinders its application …

MLN4924, a newly discovered small molecule inhibitor of NEDD8-activating enzyme (NAE),
inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin neddylation. As a …

Resistance of cancer cells to chemotherapy is a significant problem in oncology and the
development of sensitising agents or small-molecules with new mechanisms of action to kill …

Background: The Akt/mammalian target of rapamycin (mTOR) signalling pathway serves as
a critical regulator of cellular growth, proliferation and survival. Akt aberrant activation has …

Salinomycin is perhaps the first promising compound that was discovered through high
throughput screening in cancer stem cells. This novel agent can selectively eliminate breast …

Background Triple-negative breast cancer (TNBC) is often aggressive and associated with a
poor prognosis. Due to the lack of available targeted therapies and to problems of resistance …

Metabolic stress induces autophagy as an alternative source of energy and metabolites.
Insufficient autophagy in nutrient-deprived cancer cells would be beneficial for cancer …

Lung cancer often has a poor prognosis, with brain metastases a major reason for mortality.
We modified lonidamine (LND), an antiglycolytic drug with limited efficacy, to mitochondria …

Autophagy has been referred to as a double-edged sword in tumorigenesis and tumor
progression. Emerging evidence suggests that pharmacological modulation of autophagy is …

Background We have previously demonstrated the anticancer effect of anthocyanins. In this
study, we explored the biological activities of delphinidin, the most common of the …