Modular Synthesis of Heparan Sulfate Oligosaccharides Having N-Acetyl and N-Sulfate Moieties

L Sun, P Chopra, GJ Boons - The Journal of organic chemistry, 2020 - ACS Publications
Heparan sulfates are structurally diverse sulfated polysaccharides that reside at the surface
of all animal cells where they can interact with a multitude of proteins, thereby modulating a …

Chemical derivatization of sulfated glycosaminoglycans

E Bedini, A Laezza, A Iadonisi - European Journal of Organic …, 2016 - Wiley Online Library
Sulfated glycosaminoglycans (GAGs) are a family of complex polysaccharides ubiquitously
distributed in extracellular matrices and at cell surfaces and playing key roles in a myriad of …

Sugar glues for broken neurons

H Vladimir, K Balagurunathan - 2013 - agris.fao.org
Proteoglycans (PGs) regulate diverse functions in the central nervous system (CNS) by
interacting with a number of growth factors, matrix proteins, and cell surface molecules …

Chase‐ing regeneration: engineering chondroitinase for mammalian expression

GM Curinga, Y Jin, C Zhang, C Mashburn… - The FASEB …, 2009 - Wiley Online Library
Neurons fail to regenerate following spinal cord injury partly due to the up‐regulation of
chondroitin sulfate proteoglycans (CSPGs). Animal models of neuronal injury show …

Chemoenzymatic synthesis of glycosaminoglycans: re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains

PL DeAngelis, J Liu, RJ Linhardt - Glycobiology, 2013 - academic.oup.com
Glycosaminoglycans (GAGs) are complex polysaccharides composed of hexosamine-
containing disaccharide repeating units. The three most studied classes of GAGs …

Targeting inhibitory chondroitin sulphate proteoglycans to promote plasticity after injury

JCF Kwok, JP Heller, RR Zhao, JW Fawcett - Axon growth and …, 2014 - Springer
Chondroitin sulphate proteoglycans (CSPGs) are one of the major families of inhibitory
extracellular matrix molecules in the central nervous system. The expression of various …

Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum

K Pojasek, Z Shriver, P Kiley, G Venkataraman… - Biochemical and …, 2001 - Elsevier
Glycosaminoglycans (GAGs) are a family of complex polysaccharides involved in a diversity
of biological processes, ranging from cell signaling to blood coagulation. Chondroitin sulfate …

Production of chondroitin sulfate and chondroitin

C Schiraldi, D Cimini, M De Rosa - Applied microbiology and …, 2010 - Springer
The production of microbial polysaccharides has recently gained much interest because of
their potential biotechnological applications. Several pathogenic bacteria are known to …

A highly active chondroitin sulfate lyase ABC for enzymatic depolymerization of chondroitin sulfate

XM Fan, JY Huang, XM Ling, W Wei, WB Su, YW Zhang - Polymers, 2022 - mdpi.com
Enzymatic preparation of low-molecular-weight chondroitin sulfate (LMWCS) has received
increasing attention. In this work, a chondroitin sulfate lyase ABC (Chon-ABC) was …

[引用][C] 4-O-sulfatase modifying selectively glycosaminoglycans and oligosaccharides: applications to synthesis and characterization of these compounds

A Perraut - 2011