The rise in resistant Gram-negative pathogens continues to challenge clinicians treating
infections. These resistant infections have inspired the development of new antimicrobial …

Given the inconsistent clinical findings, our goal was to characterize the pharmacodynamics
(PDs) of prolonged-infusion piperacillin-tazobactam (TZP) in an in vitro pharmacodynamic …

Background: The aims of this study were to describe pharmacokinetic/pharmacodynamic
target attainment in intensive care unit (ICU) patients treated with continuously infused ß …

Background Empiric therapy for healthcare-associated infections remains challenging,
especially with the continued development of Gram-negative organisms producing extended …

Abstract Background and Objectives Although dose optimization studies have been
performed for piperacillin and tazobactam separately, a combined integral analysis is not yet …

Administration of β-lactam antibiotics by extended infusion optimizes the pharmacodynamic
properties and bactericidal activity of these agents resulting in a potential improvement in …

We read with interest the study by Fresan et al. who assessed therapeutic drug monitoring
(TDM) and pharmacokinetic/pharmacodynamic (PK/PD) target attainment of ceftazidime …

Tazobactam/ceftolozane is a combination of a β-lactamase inhibitor and a cephalosporin
antibiotic, with recommended dosage for patients with normal renal function of tazobactam …

The objective of this study was to assess the relationship between joint pharmacokinetic/
pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) ceftazidime …

The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …