Since exposure to benzo [a] pyrene is suspected to be associated with several health
issues, significant efforts have been made to develop efficient strategies for the assessment …

A fast, highly specific analytical method was developed to quantify 1, N 6-ethenoadenine
(εA) in urine of rats. εA is a highly mutagenic DNA adduct generated by vinyl chloride (VC) …

Etheno DNA adducts are a prevalent type of DNA damage caused by vinyl chloride (VC)
exposure and oxidative stress. Etheno adducts are mutagenic and may contribute to the …

trans, trans-2, 4-Decadienal (DDE) is an important breakdown product of lipid peroxidation.
This aldehyde is cytotoxic to mammalian cells and is known to be implicated in DNA …

Ethylene oxide (EtO) is classified as a known human carcinogen. The formation of EtO‐DNA
adducts is considered as an important early event in the EtO carcinogenic process. An …

Reaction of crotonaldehyde or two molecules of acetaldehyde with DNA generates 3-(2′-
deoxyribos-1′-yl)-5, 6, 7, 8-tetrahydro-8-hydroxy-6-methylpyrimido [1, 2-a] purine-10 (3H) …

Analysis of cellular 7, 8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo) as a biomarker of
oxidative DNA damage has been fraught with numerous methodological problems. This is …

1, 3-Butadiene (BD) is a high volume industrial chemical commonly used in polymer and
rubber production. It is also present in cigarette smoke, automobile exhaust, and urban air …

Sensitive methods for quantifying DNA adducts from (i) benzo [a] pyrene (BP),(ii) alkylation
exposure, and (iii) etheno (ε)-DNA adduct-forming chemicals were developed and applied to …

Cigarette smoke contains ethylating agents which damage DNA producing ethylated DNA
adducts, such as N3-ethyladenine (3-EtAde), N7-ethylguanine (7-EtGua), and regioisomers …