Neoantigens are tumor-specific proteins and peptides that can be highly immunogenic.
Immune-mediated tumor rejection is strongly associated with cytotoxic responses to …

Cancer immunotherapy has achieved multiple clinical benefits and has become an
indispensable component of cancer treatment. Targeting tumor-specific antigens, also …

The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

Within the past decade, the field of immunotherapy has revolutionized the treatment of many
cancers with the development and regulatory approval of various immune-checkpoint …

Personal neoantigen–based cancer vaccines are designed to target antigens arising from
tumor-specific mutations within individual cancers and present a tremendous opportunity to …

Although significant advances in immunotherapy have revolutionized the treatment of many
cancer types over the past decade, the field of vaccine therapy, an important component of …

Cancer immunotherapies refer to the concept of retraining the immune system to target
malignant cells. Multiple immunotherapeutic options exist including immune modulating …

Neoantigen cancer vaccines harbor promise as next-generation immuno-oncology
therapies, whereby cancer vaccines are tailored to the patient's tumor antigen and represent …

Alternatives to conventional cancer treatments are highly sought after for high-risk
malignancies that have a poor response to established treatment modalities. With research …

The process of tumorigenesis leaves a series of indelible genetic changes in tumor cells,
that when expressed, have the potential to be tumor-specific immune targets. Neoantigen …