Dual mitigation of immunosuppression combined with photothermal inhibition for highly effective primary tumor and metastases therapy
J Huang, L Zhang, W Zhou, J Wang, R Zhang, Z Wang… - Biomaterials, 2021 - Elsevier
T-cell based immune response can attack cancer cells formidably when certain immune
checkpoint (eg, PD-1/PD-L1) is blocked. Unfortunately, PD-1/PD-L1 blockade only provoke …
checkpoint (eg, PD-1/PD-L1) is blocked. Unfortunately, PD-1/PD-L1 blockade only provoke …
[HTML][HTML] Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy
J Huang, X Leng, T Jiang, L Xu, J Zheng, M Fang… - Materials Today Bio, 2023 - Elsevier
Immunotherapy shows great promise on treating tumors. However, insufficient antigen
exposure and immunosuppressive tumor microenvironment (TME) caused by hypoxia …
exposure and immunosuppressive tumor microenvironment (TME) caused by hypoxia …
Photothermal “nano-dot” reactivate “immune-hot” for tumor treatment via reprogramming cancer cells metabolism
Y Lu, Y Wang, W Liu, H Ma, B Yang, K Shao, S Long… - Biomaterials, 2023 - Elsevier
Cancer immunotherapy, despite its enormous application prospect, is trapped in the
abnormal lactic acid metabolism of tumor cells that usually causes an immunosuppressive …
abnormal lactic acid metabolism of tumor cells that usually causes an immunosuppressive …
Combining PD-L1 inhibitors with immunogenic cell death triggered by chemo-photothermal therapy via a thermosensitive liposome system to stimulate tumor-specific …
J Yu, X He, Z Wang, Y Wang, S Liu, X Li, Y Huang - Nanoscale, 2021 - pubs.rsc.org
Immune checkpoint blockade (ICB) therapy in combination with immunogenic death (ICD)
triggered by photothermal therapy (PTT) and oxaliplatin (OXA) treatment was expected to …
triggered by photothermal therapy (PTT) and oxaliplatin (OXA) treatment was expected to …
Targeted NIR-responsive theranostic immuno-nanomedicine combined TLR7 agonist with immune checkpoint blockade for effective cancer photothermal …
V Yasothamani, R Vivek - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Nanomedicine with immunotherapy offers opportunities to target cancer in an effective
manner; however, it remains challenging. We herein report a photothermal material loaded …
manner; however, it remains challenging. We herein report a photothermal material loaded …
Lipid–Polymer Hybrid Nanoparticles with Both PD-L1 Knockdown and Mild Photothermal Effect for Tumor Photothermal Immunotherapy
D Chuan, R Fan, B Chen, Y Ren, M Mu… - … Applied Materials & …, 2023 - ACS Publications
In developing countries, the incidence of colorectal cancer (CRC) is on the rise. The
combination of programmed cell death ligand-1 (PD-L1) siRNA (siPD-L1) and mild …
combination of programmed cell death ligand-1 (PD-L1) siRNA (siPD-L1) and mild …
Nanomedicine-based tumor photothermal therapy synergized immunotherapy
T Shang, X Yu, S Han, B Yang - Biomaterials science, 2020 - pubs.rsc.org
The emerging anti-tumor immunotherapy has made significant progress in clinical
application. However, single immunotherapy is not effective for all anti-tumor treatments …
application. However, single immunotherapy is not effective for all anti-tumor treatments …
Mild hyperthermia promotes immune checkpoint blockade-based immunotherapy against metastatic pancreatic cancer using size-adjustable nanoparticles
Q Yu, X Tang, W Zhao, Y Qiu, J He, D Wan, J Li… - Acta Biomaterialia, 2021 - Elsevier
Immune checkpoint blockade treatment is one of the most promising immunotherapies,
which exhibits promising therapeutic effects on inhibition of metastasis. However …
which exhibits promising therapeutic effects on inhibition of metastasis. However …
Polymeric PD-L1 blockade nanoparticles for cancer photothermal-immunotherapy
Checkpoint inhibitors, such as antibodies blocking the PD-1/PD-L1 pathway, are among the
most promising immunotherapies to treat metastatic cancers, but their response rate remains …
most promising immunotherapies to treat metastatic cancers, but their response rate remains …
Tumor microenvironment-responsive prodrug nanoplatform via co-self-assembly of photothermal agent and IDO inhibitor for enhanced tumor penetration and cancer …
Y Liu, Y Lu, X Zhu, C Li, M Yan, J Pan, G Ma - Biomaterials, 2020 - Elsevier
Nanomedicine-based phototherapy in combination with immune checkpoint blockade
therapy has been reported as a promising strategy for improved cancer immunotherapy …
therapy has been reported as a promising strategy for improved cancer immunotherapy …