Low-density lipoprotein receptor-related protein 1 (LRP1) is known to regulate cell survival
and inflammation. The present study investigated the involvement of LRP1 in the regulation …

NOD-like receptor family caspase recruitment domain family domain containing 5 (NLRC5)
has been found to be a critical mediator of inflammatory response. However, the role of …

The aim of this study was to investigate the activation of the Wnt/β‐catenin pathway in
osteoarthritis and the role of low‐density lipoprotein receptor‐related protein 5 (LRP5) in …

Osteoarthritis (OA) is a chronic debilitating disease characterized by joint degeneration.
Excessive chondrocyte apoptosis and inflammation contributes to articular cartilage …

Osteoarthritis (OA), a chronic degenerative joint disease, always occurred in the aging
population. There is evidence suggests that chondrocytes' survival, inflammation, and …

Objective. The wingless-type MMTV integration site family (WNT) signalling pathway plays
an important role in embryonic joint and bone development and has been associated with …

Introduction Wnt ligands bind to low-density lipoprotein receptor–related protein (LRP) 5 or
6, triggering a cascade of downstream events that include β-catenin signaling. Here we …

The contribution of the NLRP3 inflammasome in osteoarthritis (OA) pathogenesis has been
uncovered in recent years. Holomycin (HL) has recently been identified as a novel NLRP3 …

Osteoarthritis (OA) is a common degenerative disease that is associated with the
degradation of articular cartilage. Accumulating evidence has confirmed that LIM …

Objective Wnt/β-catenin signaling plays an integral and complex role in cartilage
development and maintenance. β-catenin signaling has been linked to osteoarthritis (OA) …