Frontotemporal dementia (FTD) is one of the commonest forms of early-onset dementia,
accounting for up to 20% of all dementia patients. Recently, it has been shown that …

Frontotemporal dementia is accompanied by motor neuron disease (FTD+ MND) in∼ 10%
of cases. There is accumulating evidence for a clinicopathological overlap between FTD and …

Mutations in the progranulin gene (PGRN), on chromosome 17q21, have recently been
identified as a major cause of familial frontotemporal dementia (FTD). These cases have a …

Frontotemporal dementia (FTD) is a clinical term encompassing dementia characterized by
the presence of two major phenotypes: 1) behavioral and personality disorder, and 2) …

Frontotemporal lobar degeneration (FTLD) refers to a clinically, pathologically, and
genetically heterogeneous group of dementias that arises from the degeneration of the …

Mutations in the progranulin (GRN) gene have recently been reported as a cause of the
frontotemporal dementia (FTD) syndrome. We performed a clinical, neuropathological and …

Frontotemporal lobar degeneration (FTLD) with ubiquitin-positive, tau-negative inclusions,
and linkage to chromosome 17 was recently found to be caused by mutations in the …

BACKGROUND: There is an increasing interest in the clinico-pathological correlation of
mutations in progranulin (PGRN) and frontotemporal lobar degeneration (FTLD) complex …

Mutations of the progranulin gene lead to progranulin haploinsufficiency and to
frontotemporal lobar degeneration (FTD) with TDP-43 positive inclusions. It is assumed that …

Studies suggest that frontotemporal lobar degeneration with transactive response DNA-
binding protein of 43 kDa (TDP-43) proteinopathy (FTLD-TDP) is heterogeneous with …