Progranulin gene (PGRN) mutations cause ubiquitin-positive frontotemporal lobar
degeneration linked to chromosome 17 (FTLDU-17). The spectrum of known mutations …

Understanding of frontotemporal lobar degeneration, the underlying pathology most often
linked to the clinical diagnosis of frontotemporal dementia, is rapidly increasing. Mutations in …

Background: Frontotemporal dementia (FTD) in several 17q21-linked families was recently
explained by truncating mutations in the progranulin gene (GRN). Objective: To determine …

Mutations in the progranulin gene (GRN) were recently identified as an important cause of
familial frontotemporal dementia (FTD). More than 60 pathogenic mutations have been …

Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder characterized
by behavioural disturbances and cognitive decline. Here we describe an Italian family with …

Two hundred and twenty-three consecutive patients fulfilling clinical diagnostic criteria for
frontotemporal lobar degeneration (FTLD), and 259 patients with motor neuron disease …

Parkinsonism can be the presenting feature of frontotemporal dementia due to Progranulin
(GRN) mutations or develop over the course of the disease, mimicking idiopathic …

To the Editor: Frontotemporal Lobar Degeneration (FTLD) recognizes a high familial
incidence, with up to 50% of patients reporting a positive family history for cognitive …

Objective: To determine whether TDP-43 type is associated with distinct patterns of brain
atrophy on MRI in subjects with pathologically confirmed frontotemporal lobar degeneration …

Abstract Background: Hippocampal sclerosis (HpScl) is common in elderly subjects with
dementia, either alone or accompanied by other pathologic processes. It is also found in> …