Severe malaria remains a major cause of mortality and morbidity for children living in many
tropical regions. With the emergence of strains of Plasmodium falciparum resistant to both …

Resistance to available antimalarial drugs is becominP; more widesnread (WHO, 1987;
BJ~~ RKMAN & PHILLIPS-HOWARD, 199 '0), leading toa delayed initial fall in parasite …

Intramuscular artemether was compared with intramuscular sulfadoxine-pyrimethamine in
Nigerian children with moderately severe malaria requiring parenteral therapy. Artemether …

Drug treatment of severe malaria must be rapidly effective. Suppositories may be valuable
for childhood malaria when circumstances prevent oral or parenteral therapy. We compared …

A randomized pilot study to compare the safety and efficacy of artesunate suppositories (15
mg/kg/day for three days) versus oral artesunate (6 mg/kg/day for three days), both in …

We have compared a multi-dose intramuscular regime of artemether against the standard
intravenous quinine treatment for cerebral malaria in an open randomized study. Parasite …

The efficacy of a 5-day treatment with intramuscular artemether (3.2-mg/kg loading dose
followed by 1.6 mg/kg daily) was compared to that of the standard 7-day treatment with …

Artemisinin derivatives, such as artesunate, have a short half-life and very rapid anti-malarial
activity. Theoretically, using such agents in conjunction with well-established anti-malarial …

Artemether is an oil-soluble methyl ether of artemesinin (qinghaosu). It has been studied
extensively in China, where it has been shown to be rapidly effective in severe falciparum …

For the treatment of patients with acute falciparum malaria, the combination of artemisinin as
a single dose with a single dose of mefloquine was studied in 4 separate prospective trials …