Nanoliposomal Bcl-xL proteolysis-targeting chimera enhances anti-cancer effects on cervical and breast cancer without on-target toxicities
J Zhang, B Zhang, C Pu, J Cui, K Huang… - … Composites and Hybrid …, 2023 - Springer
Bcl-xL is a well-characterized target gene of cancer. DT2216, a selective proteolysis-
targeting chimera (PROTAC) has been developed for targeting Bcl-xL without causing …
targeting chimera (PROTAC) has been developed for targeting Bcl-xL without causing …
Hybrid nanoparticles coated with hyaluronic acid lipoid for targeted co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells
Z Yang, N Sun, R Cheng, C Zhao, J Liu… - Journal of Materials …, 2017 - pubs.rsc.org
Conventional chemotherapy drugs such as paclitaxel (PTX) can effectively inhibit tumor
growth by killing the majority of the proliferating cancer cells; however, it also results in multi …
growth by killing the majority of the proliferating cancer cells; however, it also results in multi …
Lysosome-independent intracellular drug/gene codelivery by lipoprotein-derived nanovector for synergistic apoptosis-inducing cancer-targeted therapy
W Wang, K Chen, Y Su, J Zhang, M Li… - Biomacromolecules, 2018 - ACS Publications
In this paper, reconstituted high-density lipoprotein (rHDL), a lipoprotein-derived nanovector,
was constructed for codelivery of paclitaxel (PTX) and wild-type p53 gene (p53). The particle …
was constructed for codelivery of paclitaxel (PTX) and wild-type p53 gene (p53). The particle …
Asynchronous blockade of PD-L1 and CD155 by polymeric nanoparticles inhibits triple-negative breast cancer progression and metastasis
C Chen, Q Guo, H Fu, J Yu, Y Sun, J Zhang, Y Duan - Biomaterials, 2021 - Elsevier
Abstract PD-L1/PD-1 blockade therapy shows durable responses to triple-negative breast
cancer (TNBC), but the response rate is low. CD155 promotes tumor metastasis intrinsically …
cancer (TNBC), but the response rate is low. CD155 promotes tumor metastasis intrinsically …
Synergistic Anticancer Response via Docetaxel-and Oleanolic Acid-Loaded Albumin/Poly (lactide) Nanoparticles in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer with a
poor prognosis. A highly effective chemotherapeutic treatment strategy is yet to be …
poor prognosis. A highly effective chemotherapeutic treatment strategy is yet to be …
Enzyme-sensitive nanoparticles, smart TAT and cetuximab conjugated immunoliposomes to overcome multidrug resistance in breast cancer cells
M Safaei, P Khosravian, SK Sheykhshabani… - Toxicology and Applied …, 2022 - Elsevier
Due to recent advances in the field of small molecule-based drugs, designing an efficient
siRNA delivery system seems essential. Here, modified sets of lipids conjugated with cell …
siRNA delivery system seems essential. Here, modified sets of lipids conjugated with cell …
[HTML][HTML] Natural polyphenol-loaded cross-linked lipoic acid vesicles treat triple-negative breast cancer by cancer cell killing and metastasis inhibition
P Jing, H Luo, J Tan, C Liao, S Zhang - Materials & Design, 2023 - Elsevier
The high incidence of metastases remains a major hurdle for triple negative breast cancer
(TNBC) treatment. Herein, we developed a fairly safe anticancer nanodrug for TNBC …
(TNBC) treatment. Herein, we developed a fairly safe anticancer nanodrug for TNBC …
Codelivery of Que and BCL-2 siRNA with Lipid–Copolymer Hybrid Nanocomplexes for Efficient Tumor Regression
K Li, X Cai, Y Fan, M Jin, Y Xie, Z Jing… - ACS Biomaterials …, 2023 - ACS Publications
The efficacy of chemotherapy is often reduced due to the chemotherapy resistance of tumor
cells, which is usually caused by abnormal gene overexpression. Herein, multifunctional …
cells, which is usually caused by abnormal gene overexpression. Herein, multifunctional …
In vivo β-catenin attenuation by the integrin α5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis
Cancer stem cells (CSCs) play pivotal roles in cancer metastasis, and strategies targeting
cancer stemness may greatly reduce cancer metastasis and improve patients' survival. The …
cancer stemness may greatly reduce cancer metastasis and improve patients' survival. The …
Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel-and cetuximab-conjugated nanodiamond nanocomposite
WS Liao, Y Ho, YW Lin, EN Raj, KK Liu, C Chen… - Acta biomaterialia, 2019 - Elsevier
Breast cancer is the most common malignancy and a leading cause of cancer-related
mortality among women worldwide. Triple-negative breast cancer (TNBC) is characterized …
mortality among women worldwide. Triple-negative breast cancer (TNBC) is characterized …