Pharmacological activation of autophagy restores cellular homeostasis in ultraviolet-(B)-induced skin photodamage

SA Umar, NH Shahid, LA Nazir, MA Tanveer… - Frontiers in …, 2021 - frontiersin.org
Ultraviolet (UV) exposure to the skin causes photo-damage and acts as the primary
etiological agent in photo-carcinogenesis. UV-B exposure induces cellular damage and is …

Integrating DNA damage response and autophagy signalling axis in ultraviolet-B induced skin photo-damage: a positive association in protecting cells against …

SA Umar, SA Tasduq - RSC advances, 2020 - pubs.rsc.org
The skin acts as both physical as well as an immunological barrier against hazardous
agents from the outside environment and protects the internal organs against damage. Skin …

Autophagy plays an essential role in ultraviolet radiation-driven skin photoaging

J Ma, Y Teng, Y Huang, X Tao, Y Fan - Frontiers in Pharmacology, 2022 - frontiersin.org
Photoaging is characterized by a chronic inflammatory response to UV light. One of the most
prominent features of cutaneous photoaging is wrinkling, which is due primarily to a loss of …

Autophagy: multiple mechanisms to protect skin from ultraviolet radiation‐driven photoaging

M Wang, P Charareh, X Lei… - Oxidative Medicine and …, 2019 - Wiley Online Library
Autophagy is an essential cellular process that maintains balanced cell life. Restriction in
autophagy may induce degenerative changes in humans. Natural or pathological aging of …

Autophagy in UV damage response

A Sample, YY He - Photochemistry and photobiology, 2017 - Wiley Online Library
UV radiation exposure from sunlight and artificial tanning beds is the major risk factor for the
development of skin cancer and skin photoaging. UV‐induced skin damage can trigger a …

Effect of Ultraviolet Radiation and Benzo [a] pyrene Co-Exposure on Skin Biology: Autophagy as a Potential Target

M Fayyad-Kazan, F Kobaisi, A Nasrallah… - International Journal of …, 2023 - mdpi.com
The skin is the outermost protective barrier of the human body. Its role is to protect against
different physical, chemical, biological and environmental stressors. The vast majority of …

Natural Autophagy Activators: A Promising Strategy for Combating Photoaging

A Vikram, SK Patel, A Singh, D Pathania, RS Ray… - Phytomedicine, 2024 - Elsevier
Background Photodamage to the skin stands out as one of the most widespread epidermal
challenges globally. Prolonged exposure to sunlight containing ultraviolet radiation (UVR) …

[HTML][HTML] Ultraviolet B radiation down-regulates ULK1 and ATG7 expression and impairs the autophagy response in human keratinocytes

X Chen, L Li, S Xu, W Bu, K Chen, M Li, H Gu - Journal of Photochemistry …, 2018 - Elsevier
Autophagy is a self-digestive pathway that helps to maintain cellular homeostasis, and many
autophagy-related gene (ATG) s involved the regulation of the autophagy process …

Synergistic interplay of UV radiation and urban particulate matter induces impairment of autophagy and alters cellular fate in senescence‐prone human dermal …

L Guerrero‐Navarro, P Jansen‐Dürr, M Cavinato - Aging Cell, 2024 - Wiley Online Library
Skin aging is a complex process influenced by intrinsic factors and environmental stressors,
including ultraviolet (UV) radiation and air pollution, among others. In this study, we …

The skin photoprotective effect of trilinolein: Induction of cellular autophagy via the AMPK-mTOR signaling pathway

X Lin, N Deng, H Li, J Duan, W Chen, T Liu… - Toxicology and Applied …, 2024 - Elsevier
Trilinolein (TL) is an active substance contained in traditional Chinese herbs; modern
studies have shown that trilinolein has anti-inflammatory and antioxidant effects on the body …