Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome

G Fabbri, H Khiabanian, AB Holmes, J Wang… - Journal of Experimental …, 2013 - rupress.org
Richter syndrome (RS) derives from the rare transformation of chronic lymphocytic leukemia
(CLL) into an aggressive lymphoma, most commonly of the diffuse large B cell lymphoma …

Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome

E Chigrinova, A Rinaldi, I Kwee, D Rossi… - Blood, The Journal …, 2013 - ashpublications.org
Richter syndrome (RS) occurs in up to 15% of patients with chronic lymphocytic leukemia
(CLL). Although RS, usually represented by the histologic transformation to a diffuse large B …

Richter syndrome: molecular insights and clinical perspectives

D Rossi, G Gaidano - Hematological oncology, 2009 - Wiley Online Library
Richter syndrome (RS) represents the clinico‐pathologic transformation of chronic
lymphocytic leukaemia (CLL) to an aggressive lymphoma, most commonly diffuse large B …

How we treat Richter syndrome

SA Parikh, NE Kay, TD Shanafelt - Blood, The Journal of the …, 2014 - ashpublications.org
Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia
(CLL) into an aggressive lymphoma, most commonly diffuse large B-cell lymphoma …

Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome

EM Parry, I Leshchiner, R Guièze, C Johnson… - Nature medicine, 2023 - nature.com
Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an
aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics …

Richter syndrome: Novel insights into the biology of transformation

EM Parry, E Ten Hacken, CJ Wu - Blood, The Journal of the …, 2023 - ashpublications.org
Although the genetic landscape of chronic lymphocytic leukemia (CLL) has been broadly
profiled by large-scale sequencing studies performed over the past decade, the molecular …

Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia

J Klintman, N Appleby, B Stamatopoulos… - Blood, The Journal …, 2021 - ashpublications.org
The transformation of chronic lymphocytic leukemia (CLL) to high-grade B-cell lymphoma is
known as Richter syndrome (RS), a rare event with dismal prognosis. In this study, we …

Biology and treatment of Richter syndrome

D Rossi, V Spina, G Gaidano - Blood, The Journal of the …, 2018 - ashpublications.org
Richter syndrome (RS) is the development of an aggressive lymphoma in patients with
chronic lymphocytic leukemia (CLL). Two pathologic variants of RS are recognized: namely …

Richter's transformation in chronic lymphocytic leukemia

AM Tsimberidou, MJ Keating - Seminars in oncology, 2006 - Elsevier
Richter's syndrome (RS) is characterized by the development of high-grade non-Hodgkin's
lymphoma (NHL) in a patient with chronic lymphocytic leukemia (CLL) or small lymphocytic …

The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation

D Rossi, V Spina, C Deambrogi, S Rasi… - Blood, The Journal …, 2011 - ashpublications.org
Richter syndrome (RS) represents the development of diffuse large B-cell lymphoma in the
context of chronic lymphocytic leukemia. The scarcity of biologic information about RS has …