This article explores the physiology of superoxide generation by endothelial nitric oxide
synthase (eNOS), the so-called “uncoupled” state of the enzyme. The fact that this alternative …

Reactive oxygen species can function as intracellular messengers, but linking these
signaling events with specific enzymes has been difficult. Purified endothelial nitric-oxide …

Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of
NO synthase (NOS; EC 1.14. 13.39). They all utilize l-arginine and molecular oxygen as …

Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a
healthy cardiovascular system. The importance of eNOS can be emphasized from the …

Endothelial nitric oxide synthase (eNOS, NOS3) is responsible for producing nitric oxide
(NO)—a key molecule that can directly (or indirectly) act as a vasodilator and anti …

2498 MARON BA et al. tion of eNOS is dynamically regulated9 and the enzyme is thus
exposed to different concentrations of ROS depending upon where in the cell the protein is …

▪ Abstract Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates
significant and diverse signaling functions in nearly every organ system in the body. The …

Impaired nitric oxide (NO) activity in proatherosclerotic states has been suggested to be
caused mainly by increased degradation of NO by oxygen radicals. In recent years …

The objective of this study was to determine whether absence of endothelial nitric oxide
synthase (eNOS) affects the expression of cell surface adhesion molecules in endothelial …

Endothelial nitric oxide synthase (eNOS) is regulated by multiple mechanisms including
Ca2+/calmodulin binding, protein-protein interactions, phosphorylation, and subcellular …