Endothelial dysfunction is seen early in the develop-ment of atherosclerosis, before overt
vascular and structural changes. Nitric oxide (NO) is recognized as one of the major …

Objective: Oxidized low-density lipoprotein (ox-LDL) increases superoxide anion (O2−)
production by the endothelial nitric oxide (NO) synthase (eNOS). We assessed whether the …

Endothelial nitric oxide synthase (eNOS) is the primary physiological source of nitric oxide
(NO) that regulates cardiovascular homeostasis. Historically eNOS has been thought to be a …

Nitric oxide (NO) produced by the endothelial isoform of nitric oxide synthase (NOS III) is a
key determinant of the anti-atherosclerotic properties of the endothelium. Recent in vivo …

The endothelial cell layer plays a major role in the development and progression of
atherosclerosis. Endothelial NO synthase (eNOS) produces nitric oxide (NO) from L …

Nitric oxide (NO) regulates vascular tone and local blood flow, platelet aggregation and
adhesion, and leukocyte-endothelial cell interactions. Abnormalities in NO production by the …

Endothelial nitric oxide synthase (eNOS) is important for cardiovascular homeostasis, vessel
remodeling, and angiogenesis. Given the impact of endothelium-derived nitric oxide (NO) in …

Endothelial nitric oxide synthase (eNOS) is a multifunctional enzyme with roles in diverse
cellular processes including angiogenesis, tissue remodeling, and the maintenance of …

Nitric oxide (NO) produced by the endothelium is an important protective molecule in the
vasculature. It is generated by the enzyme endothelial NO synthase (eNOS). Similar to all …

Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation
of vascular tone is one of the most important. Under physiological conditions vascular NO is …