Multivariate genetic analysis of apo AI concentration and HDL subfractions: evidence for major locus pleiotropy

J Blangero, S Williams‐Blangero… - Genetic …, 1993 - Wiley Online Library
A major locus influencing apolipoprotein AI (apo AI) serum levels was detected using data
from the Donner Laboratory Family Study. This locus accounts for 46% of the phenotypic …

Genetic determination of plasma apolipoprotein AI in a population-based sample.

PP Moll, VV Michels, WH Weidman… - American journal of …, 1989 - ncbi.nlm.nih.gov
Apolipoprotein AI (apo AI) is the major protein of high-density lipoprotein (HDL). Using
radioimmunoassay, we measured plasma apo AI levels in 1,880 individuals in 283 …

DNA polymorphisms of the apolipoprotein AII and AI-CIII-AIV genes: a study in men selected for differences in high-density-lipoprotein cholesterol concentration.

AM Kessling, J Rajput-Wiliams, D Bainton… - American journal of …, 1988 - ncbi.nlm.nih.gov
We have investigated the frequencies of RFLPs of the apolipoprotein (apo) AII gene and of
the apo AI-CIII-AIV gene cluster in 109 men, selected from a random sample of 1,910 men …

The genetic determination of plasma apolipoprotein AI levels measured by radioimmunoassay: a study of high-risk pedigrees.

PP Moll, CF Sing, RR Williams, SJ Mao… - American journal of …, 1986 - ncbi.nlm.nih.gov
Apolipoprotein AI (apo AI) is the major protein component of the high-density lipoprotein
(HDL) found in all primates. Using radioimmunoassay, we measured plasma apo AI levels in …

Genetic analysis of a polymorphism in the human apolipoprotein AI gene promoter: effect on plasma HDL-cholesterol levels.

DE Barre, R Guerra, R Verstraete, Z Wang… - Journal of lipid …, 1994 - Elsevier
Previous studies have indicated that a G to A substitution at position-76 in the gene
encoding apolipoprotein AI (apoA-I) confers increased plasma high density lipoprotein …

Identification of Common Genetic Polymorphisms that Determine Plasma Levels of ApoAI and HDL-C

S Humphries, V Gudnason, H Paul-Hayase… - … mutants III: diagnosis …, 1993 - Springer
A large number of epidemiological studies have demonstrated that low serum levels of high
density lipoprotein cholesterol (HDL-C) and apolipoprotein AI (apo AI) are risk factors for the …

Genetic studies of human apolipoproteins. VII. Population distribution of polymorphisms of apolipoproteins AI, A-II, A-IV, C-II, E, and H in Nigeria.

B Sepehrnia, MI Kamboh… - American journal of …, 1988 - ncbi.nlm.nih.gov
Genetic variation at various human apolipoprotein gene loci plays a vital role in modulating
lipid metabolism. However, information regarding genetic variation at apolipoprotein loci is …

Genetic analysis of apolipoprotein AI in two dietary environments.

J Blangero, JW MacCluer, CM Kammerer… - American journal of …, 1990 - ncbi.nlm.nih.gov
Although of great clinical and biological importance, the role of genotype-diet interaction in
lipoprotein metabolism and atherosclerosis is still poorly understood. We analyzed serum …

Human apolipoprotein AI gene promoter polymorphism: association with hyperalphalipoproteinemia.

F Pagani, A Sidoli, GA Giudici, L Barenghi… - Journal of Lipid …, 1990 - ASBMB
An apolipoprotein AI gene promoter polymorphism, due to an adenine (A) to guanine (G)
transition 78 base pairs upstream from the transcription initiation site, was studied by …

Allele frequencies of apolipoprotein AI and A-II gene locus DNA polymorphisms in Boston-based whites

RA Hegele, CH Hennekens, JL Breslow - Human heredity, 1989 - karger.com
Allele Frequencies of Apolipoprotein AI and A-II Gene Locus DNA Polymorphisms in Boston-Based
Whites Page 1 Hum Hered 1989;39:174-178 © 1989 S. Karger AG. Basel 0001-5652/89/0393-0174 …