It is well known that hepatic stellate cells (HSC) develop into cells, which are thought to
contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the …

BACKGROUND/AIMS: Liver fibrosis is characterized by accumulation of extracellular matrix
proteins synthesized by activated hepatic stellate cells (HSCs). To understand molecular …

The Wnt system is highly complex and is comprised of canonical and non-canonical
pathways leading to the activation of gene expression. Our aim was to examine changes in …

AIM: To identify differentially expressed genes in quiescent and activated hepatic stellate
cells (HSCs) and explore their functions. METHODS: HSCs were isolated from the normal …

Activation of hepatic stellate cells (HSC), a key event in liver fibrosis, is caused by
diminished adipogenic transcription. This study investigated whether Wnt signaling …

Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic
morphological transformation into proliferative, contractile and ECM-producing …

Abstract β‑catenin, a core component of Wnt/β‑catenin signaling, has been shown to be an
important regulator of cellular proliferation and differentiation. Abnormal activation of Wnt/β …

Wnt/β-catenin signaling has come to the forefront of liver biology in recent years. This
pathway regulates key pathophysiological events inherent to the liver including …

Liver-specific β-catenin knockout (β-Catenin-LKO) mice have revealed an essential role of β-
catenin in metabolic zonation where it regulates pericentral gene expression and in initiating …

BACKGROUND/AIMS: Sept4, a subunit of the septin cytoskeleton specifically expressed in
quiescent hepatic stellate cells (HSCs), is downregulated through transdifferentiation to …