Serrated lesions of the colorectum are the precursors of perhaps one-third of colorectal
cancers (CRCs). Cancers arising in serrated lesions are usually in the proximal colon, and …

In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …

The concept of serrated colorectal neoplasia and a serrated pathway to colorectal cancer
(CRC) is relatively new and continuing to evolve, but it has become highly relevant to …

Identification of the serrated neoplasia pathway has improved our understanding of the
pathogenesis of colorectal cancer (CRC). Insights include an increased recognition of the …

Colorectal cancer (CRC) is a heterogeneous disorder than arises via multiple distinct
pathways, such as the serrated pathway, in which serrated polyps (including variants of …

Here, we provide an up-to-date review of the histopathology and molecular pathology of
serrated colorectal lesions. First, we introduce the updated contents of the 2019 World …

Colorectal cancer (CRC) is considered a heterogeneous disease, both regarding
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …

Approximately 30% of colorectal carcinomas develop via the serrated neoplasia pathway
characterized by widespread DNA methylation and frequent BRAF mutation. Serrated …

BACKGROUND & AIMS: There is evidence that serrated polyps (serrated adenomas and
hyperplastic polyps) have different malignant potential than traditional adenomas. We used …

The distinction between serrated polyps of the colon is complex, particularly between
hyperplastic polyps (HP) and sessile serrated adenomas (SSA). Recent data show that SSA …