Background Increased iron availability modifies cardiorespiratory function in healthy
volunteers and improves exercise capacity and quality of life in patients with heart failure or …

Iron is an essential cofactor in numerous biological functions within aerobic organisms (1).
As a component of hemoglobin, iron is crucial to oxygen transportation, and like oxygen, iron …

Background Pulmonary arterial hypertension (PAH) is a progressive condition harboring a
poor prognosis. Iron deficiency in PAH correlates with disease severity and mortality. While …

An intriguing finding was that systemic vessels were completely unaffected in iron-deficient
animals, similar to what is observed in patients with PAH. Michelakis et al, 21 had previously …

Key points Iron acts as a cofactor in the stabilization of the hypoxic‐inducible factor family,
and plays an influential role in the modulation of hypoxic pulmonary vasoconstriction. It is …

Rationale: Iron deficiency without anemia is prevalent in patients with idiopathic pulmonary
arterial hypertension and associated with reduced exercise capacity and survival …

Physical exercise is a well-recognized effective non-pharmacological therapy for
cardiovascular diseases. However, because iron is essential element in many physiological …

Several recent observations provide the association of iron deficiency with pulmonary
hypertension (PH) in human and animal studies. However, it remains completely unknown …

Maximal exercise capacity is reduced at altitude or during hypoxia at sea level. It has been
suggested that this might reflect increased right ventricular afterload due to hypoxic …

Objective: To determine the effect of iron supplementation on iron status and endurance
capacity. Design: Randomized, double-blind iron supplementation. Setting: University of …