A balance of protein synthesis and degradation is critical for the dynamic regulation and
implementation of long-term memory storage. The role of the ubiquitin-proteasome system …

Protein degradation by the ubiquitin–proteasome pathway plays important roles in synaptic
plasticity, but the molecular mechanisms by which proteolysis regulates synaptic strength …

Proteolysis by the ubiquitin-proteasome pathway appears to have a complex role in synaptic
plasticity, but its various functions remain to be elucidated. Using late phase long-term …

The ubiquitin-proteasome pathway (UPP) of protein degradation has many roles in synaptic
plasticity that underlies memory. Work on both invertebrate and vertebrate model systems …

Protein degradation plays a critical role in synaptic plasticity, but the molecular mechanisms
are not well understood. Previously we showed that proteasome inhibition enhances the …

Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …

Activity-dependent regulation of synaptic efficacy is believed to underlie learning and
memory formation. Here we show that protein degradation by the proteasome is required for …

Synaptic plasticity—the modulation of synaptic strength between a presynaptic terminal and
a postsynaptic dendrite—is thought to be a mechanism that underlies learning and memory …

It is clear that de novo protein synthesis has an important function in synaptic transmission
and plasticity. A substantial amount of work has shown that mRNA translation in the …

Chronic increases or decreases in neuronal activity initiates compensatory changes in
synaptic strength that emerge slowly over a 12–24 h period, but the mechanisms underlying …