Tractable and accurate disease models are essential for understanding disease
pathogenesis and for developing new therapeutics. As stem cells are capable of self …

Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …

Traditionally, human disorders were studied using animal models or somatic cells taken
from patients. Such studies enabled the analysis of the molecular mechanisms of numerous …

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) can
theoretically be converted into any somatic cell type. hESCs and hiPSCs carrying genetic …

Induced pluripotent stem cell (iPSC) technology has provided previously unanticipated
possibilities to model human disease in the culture dish. Reprogramming somatic cells from …

Cellular reprogramming and generation of induced pluripotent stem cells (iPSCs) from adult
cell types have enabled the creation of patient-specific stem cells for use in disease …

The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

Reprogramming of human somatic cells uses readily accessible tissue, such as skin or
blood, to generate embryonic-like induced pluripotent stem cells (iPSCs). This procedure …

Highlights•Step-by-step review of points to consider for successful in vitro disease
models.•Direct reprogramming/transdifferentiation versus directed in vitro differentiation.• …

Mechanistic insights into human disease may enable the development of treatments that are
effective in broad patient populations. The confluence of gene-editing technologies, induced …