The role of oxidative stress in Alzheimer disease

WR Markesbery - Archives of neurology, 1999 - jamanetwork.com
Increasing evidence demonstrates that oxidative stress causes damage to cell function with
aging and is involved in a number of age-related disorders including atherosclerosis, ar …

Oxidative stress hypothesis in Alzheimer's disease

WR Markesbery - Free radical biology and medicine, 1997 - Elsevier
The major hurdle in understanding Alzheimer's disease (AD) is a lack of knowledge about
the etiology and pathogenesis of selective neuron death. In recent years, considerable data …

Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows

D Pratico - Annals of the New York Academy of Sciences, 2008 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of neurodegenerative disease
associated with dementia in the elderly. Although the initiating events are still unknown, it is …

Signal transduction cascades associated with oxidative stress in Alzheimer's disease

RB Petersen, A Nunomura, H Lee… - Journal of …, 2007 - content.iospress.com
It has now been established through multiple lines of evidence that oxidative stress is an
early event in Alzheimer's disease, occurring prior to the canonical cytopathology. Thus …

Oxidative stress and the pathogenesis of Alzheimer′ s disease

Y Zhao, B Zhao - Oxidative medicine and cellular longevity, 2013 - Wiley Online Library
Alzheimer′ s disease (AD) is the most common neurodegenerative disease that causes
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …

Oxidative stress, antioxidants, and Alzheimer disease

CA Rottkamp, A Nunomura, AK Raina… - Alzheimer Disease & …, 2000 - journals.lww.com
Recent evidence in the field of Alzheimer disease research has highlighted the importance
of oxidative processes in its pathogenesis. Examination of cellular changes shows that …

Alzheimer disease and the role of free radicals in the pathogenesis of the disease

G Perry, PI Moreira, MS Santos… - CNS & Neurological …, 2008 - ingentaconnect.com
Oxidative stress occurs early in the progression of Alzheimer disease, significantly before
the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. All …

Oxidative stress in Alzheimer's disease

Z Chen, C Zhong - Neuroscience bulletin, 2014 - Springer
Oxidative stress plays a significant role in the pathogenesis of Alzheimer's disease (AD), a
devastating disease of the elderly. The brain is more vulnerable than other organs to …

Oxidative stress and metabolic syndrome: cause or consequence of Alzheimer′ s disease?

D Luque-Contreras, K Carvajal… - Oxidative medicine …, 2014 - Wiley Online Library
Alzheimer's disease (AD) is a major neurodegenerative disease affecting the elderly.
Clinically, it is characterized by a progressive loss of memory and cognitive function …

[图书][B] Free radicals in Alzheimer's disease

W Retz, W Gsell, G Münch, M Rösler, P Riederer - 1998 - Springer
Alzheimer's disease is a neurodegenerative disorder comprising multisystem atrophies
probably caused by multifactorial processes. The disease is characterized by typical …