Genetic landscapes of relapsed and refractory diffuse large B-cell lymphomas
Purpose: Relapsed or refractory diffuse large B-cell lymphoma (rrDLBCL) is fatal in 90% of
patients, and yet little is known about its biology. Experimental Design: Using exome …
patients, and yet little is known about its biology. Experimental Design: Using exome …
Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) patients are typically treated with
immunochemotherapy containing rituximab (rituximab, cyclophosphamide …
immunochemotherapy containing rituximab (rituximab, cyclophosphamide …
[HTML][HTML] Whole-exome analysis reveals novel somatic genomic alterations associated with outcome in immunochemotherapy-treated diffuse large B-cell lymphoma
Lack of remission or early relapse remains a major clinical issue in diffuse large B-cell
lymphoma (DLBCL), with 30% of patients failing standard of care. Although clinical factors …
lymphoma (DLBCL), with 30% of patients failing standard of care. Although clinical factors …
[HTML][HTML] Proposal and validation of a method to classify genetic subtypes of diffuse large B cell lymphoma
L Pedrosa, I Fernández-Miranda, D Pérez-Callejo… - Scientific reports, 2021 - nature.com
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease whose prognosis is
associated with clinical features, cell-of-origin and genetic aberrations. Recent integrative …
associated with clinical features, cell-of-origin and genetic aberrations. Recent integrative …
Whole exome sequencing of relapsed/refractory patients expands the repertoire of somatic mutations in diffuse large B‐cell lymphoma
S Mareschal, S Dubois, PJ Viailly… - Genes …, 2016 - Wiley Online Library
Despite the many efforts already spent to enumerate somatic mutations in diffuse large B‐
cell lymphoma (DLBCL), previous whole‐genome and whole‐exome studies conducted on …
cell lymphoma (DLBCL), previous whole‐genome and whole‐exome studies conducted on …
Relapse timing is associated with distinct evolutionary dynamics in diffuse large B-cell lymphoma
PURPOSE Diffuse large B-cell lymphoma (DLBCL) is cured in more than 60% of patients,
but outcomes remain poor for patients experiencing disease progression or relapse …
but outcomes remain poor for patients experiencing disease progression or relapse …
Genetic heterogeneity of diffuse large B-cell lymphoma
J Zhang, V Grubor, CL Love… - Proceedings of the …, 2013 - National Acad Sciences
Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma in adults.
The disease exhibits a striking heterogeneity in gene expression profiles and clinical …
The disease exhibits a striking heterogeneity in gene expression profiles and clinical …
Genetics and pathogenesis of diffuse large B-cell lymphoma
R Schmitz, GW Wright, DW Huang… - New England journal …, 2018 - Mass Medical Soc
Background Diffuse large B-cell lymphomas (DLBCLs) are phenotypically and genetically
heterogeneous. Gene-expression profiling has identified subgroups of DLBCL (activated B …
heterogeneous. Gene-expression profiling has identified subgroups of DLBCL (activated B …
Next-generation sequencing in diffuse large B-cell lymphoma highlights molecular divergence and therapeutic opportunities: a LYSA study
S Dubois, PJ Viailly, S Mareschal, E Bohers… - Clinical cancer …, 2016 - AACR
Purpose: Next-generation sequencing (NGS) has detailed the genomic characterization of
diffuse large B-cell lymphoma (DLBCL) by identifying recurrent somatic mutations. We set …
diffuse large B-cell lymphoma (DLBCL) by identifying recurrent somatic mutations. We set …
[HTML][HTML] Genetic lesions in diffuse large B-cell lymphomas
M Testoni, E Zucca, KH Young, F Bertoni - Annals of Oncology, 2015 - Elsevier
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults, accounting
for 35%–40% of all cases. The combination of the anti-CD20 monoclonal antibody rituximab …
for 35%–40% of all cases. The combination of the anti-CD20 monoclonal antibody rituximab …