Insights into cellular uptake of nanoparticles

M Hasanzadeh Kafshgari, FJ Harding… - Current drug …, 2015 - ingentaconnect.com
Nanomaterials promise to improve disease diagnosis and treatment by enhancing the
delivery of drugs, genes, biomolecules and imaging agents to specific subcellular targets. In …

Nanoparticle uptake: the phagocyte problem

HH Gustafson, D Holt-Casper, DW Grainger… - Nano today, 2015 - Elsevier
Phagocytes are key cellular participants determining important aspects of host exposure to
nanomaterials, initiating clearance, biodistribution and the tenuous balance between host …

Nanoparticles: pharmacological and toxicological significance

C Medina, MJ Santos‐Martinez… - British journal of …, 2007 - Wiley Online Library
Nanoparticles are tiny materials (< 1000 nm in size) that have specific physicochemical
properties different to bulk materials of the same composition and such properties make …

Influence of nanoparticle shape, size, and surface functionalization on cellular uptake

N Ma, C Ma, C Li, T Wang, Y Tang… - … of nanoscience and …, 2013 - ingentaconnect.com
With the rapid development of biotechnology and nanomedicine, extensive research has
focused on the investigations of delivering large-cargo molecules using nanoparticles …

Nanoparticles in modern medicine: state of the art and future challenges

SK Murthy - International journal of nanomedicine, 2007 - Taylor & Francis
Nanoparticles are materials with overall dimensions in the nanoscale, ie, under 100 nm. In
recent years, these materials have emerged as important players in modern medicine, with …

Identification of multiple cellular uptake pathways of polystyrene nanoparticles and factors affecting the uptake: Relevance for drug delivery systems

R Firdessa, TA Oelschlaeger, H Moll - European journal of cell biology, 2014 - Elsevier
Nanoparticles may address challenges by human diseases through improving diagnosis,
vaccination and treatment. The uptake mechanism regulates the type of threat a particle …

Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution

MA Dobrovolskaia, P Aggarwal, JB Hall… - Molecular …, 2008 - ACS Publications
Nanoparticles have unique physicochemical properties which make them promising
platforms for drug delivery. However, immune cells in the bloodstream (such as monocytes …

The ancillary effects of nanoparticles and their implications for nanomedicine

EP Stater, AY Sonay, C Hart, J Grimm - Nature Nanotechnology, 2021 - nature.com
Nanoparticles are often engineered as a scaffolding system to combine targeting, imaging
and/or therapeutic moieties into a unitary agent. However, mostly overlooked, the …

Multifunctional nanoparticles: recent progress in cancer therapeutics

GSR Raju, L Benton, E Pavitra, JS Yu - Chemical communications, 2015 - pubs.rsc.org
Although much progress has been made in treating cancers, cancer death rates in and
around the United States are still high. Current treatments are either ineffective against some …

Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population

JA Kim, C Åberg, A Salvati, KA Dawson - Nature nanotechnology, 2012 - nature.com
Nanoparticles are considered a primary vehicle for targeted therapies because they can
pass biological barriers and enter and distribute within cells by energy-dependent …