Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease

K Maiese - Neural regeneration research, 2015 - journals.lww.com
Diabetes mellitus affects almost 350 million individuals throughout the globe resulting in
significant morbidity and mortality. Of further concern is the growing population of individuals …

Cornerstone Cellular pathways for metabolic disorders and Diabetes Mellitus: non-coding RNAs, wnt signaling, and AMPK

K Maiese - Cells, 2023 - mdpi.com
Metabolic disorders and diabetes (DM) impact more than five hundred million individuals
throughout the world and are insidious in onset, chronic in nature, and yield significant …

Triple play: Promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus

K Maiese - Biomedicine & pharmacotherapy, 2008 - Elsevier
Oxidative stress is a principal pathway for the dysfunction and ultimate destruction of cells in
the neuronal and vascular systems for several disease entities, not promoting the ravages of …

On the common journey of neural cells through ischemic brain injury and Alzheimer's disease

J Kriska, Z Hermanova, T Knotek, J Tureckova… - International Journal of …, 2021 - mdpi.com
Ischemic brain injury and Alzheimer's disease (AD) both lead to cell death in the central
nervous system (CNS) and thus negatively affect particularly the elderly population. Due to …

Programming apoptosis and autophagy with novel approaches for diabetes mellitus

K Maiese - Current Neurovascular Research, 2015 - ingentaconnect.com
According to the World Health Organization, diabetes mellitus (DM) in the year 2030 will be
ranked the seventh leading cause of death in the world. DM impacts all systems of the body …

Diabetes mellitus: channeling care through cellular discovery

K Maiese, YC Shang, ZZ Chong… - Current Neurovascular …, 2010 - ingentaconnect.com
Diabetes mellitus (DM) impacts a significant portion of the world's population and care for
this disorder places an economic burden on the gross domestic product for any particular …

Wnt‐induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease

P Cisternas, JM Zolezzi, M Martinez… - Journal of …, 2019 - Wiley Online Library
Dysregulated Wnt signaling is linked to major neurodegenerative diseases, including
Alzheimer disease (AD). In mouse models of AD, activation of the canonical Wnt signaling …

Wnt1 Neuroprotection Translates into Improved Neurological Function during Oxidant Stress and Cerebral Ischemia Through AKT1 and Mitochondrial Apoptotic …

ZZ Chong, YC Shang, J Hou… - Oxidative medicine and …, 2010 - Wiley Online Library
Although essential for the development of the nervous system, Wnt1 also has been
associated with neurodegenerative disease and cognitive loss during periods of oxidative …

Glial cell alterations in diabetes-induced neurodegeneration

M Llorián-Salvador, S Cabeza-Fernández… - Cellular and Molecular …, 2024 - Springer
Type 2 diabetes mellitus is a global epidemic that due to its increasing prevalence
worldwide will likely become the most common debilitating health condition. Even if diabetes …

New insights for oxidative stress and diabetes mellitus

K Maiese - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …