Isoquinoline and its derivatives are ubiquitous in natural alkaloids, synthetic materials and
pharmaceuticals with a broad spectrum of biological activities. In particular, isoquinolinium …

Quinoline derivatives are frequently found in natural products and biologically active
compounds; however, construction of quinoline fused polyheterocycles is a challenging goal …

In the past decades, an enormous number of reports have been dedicated towards the
synthesis of nitrogen containing heterocycles. This immense interest have emerged owing to …

Isoquinoline-enrooted organic small-molecules represent a challenging molecular target in
the organic synthesis arsenal attributed of its structural diversity and therapeutic importance …

1, 2, 3, 4-Tetrahydroisoquinoline is an important structural motif of various natural products
and therapeutic lead compounds. In recent years, considerable research interest has been …

We developed a one-pot, two-stage synthetic route to substituted 4-aminoquinolines
involving an imidoylative Sonogashira coupling followed by acid-mediated cyclization. This …

Isoquinolones (isoquinolin-1 (2 H)-ones) are one of the important nitrogen-heterocyclic
compounds having versatile biological and physiological activities, and their synthetic …

The method for the synthesis of complex alkaloid-like aza-heterocycles has been developed
through the Povarov reaction of in situ generated 2-oxoimidazolium cations. The reaction …

An efficient, single step synthesis of hitherto unknown indole-annulated pentacyclic
indolylhydroquinolines via tandem C-alkylation and intramolecular S-alkylation of indolin-2 …

Presented herein is a novel synthesis of dihydroquinolinone derivatives through an
unprecedented cascade reaction of o-silylaryl triflates with pyrazolidinones. Mechanistically …