Graft of a tissue-engineered neural scaffold serves as a promising strategy to restore myelination after rat spinal cord transection

BQ Lai, JM Wang, EA Ling, JL Wu… - Stem cells and …, 2014 - liebertpub.com
Remyelination remains a challenging issue in spinal cord injury (SCI). In the present study,
we cocultured Schwann cells (SCs) and neural stem cells (NSCs) with overexpression of …

The integration of NSC-derived and host neural networks after rat spinal cord transection

BQ Lai, JM Wang, JJ Duan, YF Chen, HY Gu, EA Ling… - Biomaterials, 2013 - Elsevier
Rebuilding structures that can bridge the injury gap and enable signal connection remains a
challenging issue in spinal cord injury. We sought to determine if genetically enhanced …

Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after rat spinal cord transection

X Zeng, XC Qiu, YH Ma, JJ Duan, YF Chen, HY Gu… - Biomaterials, 2015 - Elsevier
Functional deficits following spinal cord injury (SCI) primarily attribute to loss of neural
connectivity. We therefore tested if novel tissue engineering approaches could enable …

Cograft of neural stem cells and schwann cells overexpressing TrkC and neurotrophin-3 respectively after rat spinal cord transection

JM Wang, YS Zeng, JL Wu, Y Li, YD Teng - Biomaterials, 2011 - Elsevier
Effectively bridging the lesion gap is still an unmet demand for spinal cord repair. In the
present study, we tested our hypothesis if cograft of Schwann cells (SCs) and neural stem …

Graft of the gelatin sponge scaffold containing genetically‐modified neural stem cells promotes cell differentiation, axon regeneration, and functional recovery in rat …

BL Du, X Zeng, YH Ma, BQ Lai… - … Research Part A, 2015 - Wiley Online Library
Biological materials combined with genetically‐modified neural stem cells (NSCs) are
candidate therapy targeting spinal cord injury (SCI). Based on our previous studies, here we …

Donor mesenchymal stem cell-derived neural-like cells transdifferentiate into myelin-forming cells and promote axon regeneration in rat spinal cord transection

XC Qiu, H Jin, RY Zhang, Y Ding, X Zeng… - Stem cell research & …, 2015 - Springer
Introduction Severe spinal cord injury often causes temporary or permanent damages in
strength, sensation, or autonomic functions below the site of the injury. So far, there is still no …

Genetically modified mesenchymal stem cells (MSCs) promote axonal regeneration and prevent hypersensitivity after spinal cord injury

G Kumagai, P Tsoulfas, S Toh, I McNiece… - Experimental …, 2013 - Elsevier
Neurotrophins and the transplantation of bone marrow-derived stromal cells (MSCs) are
both candidate therapies targeting spinal cord injury (SCI). While some studies have …

Neurotrophin-3 gene-modified Schwann cells promote TrkC gene-modified mesenchymal stem cells to differentiate into neuron-like cells in poly (lactic-acid-co …

Y Zhang, L He, B Xing, X Zeng, C Zeng, W Zhang… - Cells Tissues …, 2012 - karger.com
Rapid progress in the field of nerve tissue engineering has opened up the way for new
therapeutic strategies for spinal cord injury (SCI). Bone marrow-derived mesenchymal stem …

Modified acellular nerve-delivering PMSCs improve functional recovery in rats after complete spinal cord transection

T Tian, Z Yu, N Zhang, Y Chang, Y Zhang… - Biomaterials …, 2017 - pubs.rsc.org
Due to the poor regeneration capacity of neurons and the inhibitory microenvironment,
spontaneous regeneration in spinal cord injury (SCI) remains challenging. Tissue …

[HTML][HTML] An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord …

G Li, B Zhang, J Sun, L Shi, M Huang, L Huang, Z Lin… - Bioactive materials, 2021 - Elsevier
The mechanism underlying neurogenesis during embryonic spinal cord development
involves a specific ligand/receptor interaction, which may be help guide neuroengineering to …