Highlights•Neglected tropical diseases affect approximately one billion people
worldwide.•Most of the available drugs have limited efficacy and cause serious adverse …

Neglected tropical diseases represent a major sanitary problem and a huge economic
burden to endemic countries, and are currently expanding to non-endemic countries owing …

Neglected tropical diseases cause significant morbidity and mortality and are a source of
poverty in endemic countries. Only a few drugs are available to treat diseases such as …

Parasitic diseases have an enormous health, social and economic impact and are a
particular problem in tropical regions of the world. Diseases caused by protozoa and …

The Sandler Center's approach to target-based drug discovery for neglected tropical
diseases is to focus on parasite targets that are homologous to human targets being actively …

Infectious diseases are an enormous burden to global health and, since drug discovery is
costly, those infectious diseases that affect the developing world are often not pursued by …

Highlights•New antiparasitic drugs with novel modes of action are needed.•Although new
compounds are being identified, mode of action (s) is often not known.•Here we describe …

Open-access drug discovery provides a substantial resource for diseases primarily affecting
the poor and disadvantaged. The open-access Pathogen Box collection is comprised of …

Diseases caused by tropical parasites affect hundreds of millions of people worldwide but
have been largely neglected for drug development because they affect poor people in poor …

Addressing parasitic diseases and those caused by bacteria, this much needed reference
and handbook provides a unique insight into the approach adopted by commercial science …