Totally substituted butenolide including two tetrasubstituted olefins is a distinct structural
motif seen in Stemona alkaloids, but efficient methods for its synthesis are not well …

Stemona alkaloids contain family members with diverse structural scaffolds. Many of them
feature a γ-lactam ring embedded in their characteristic 5–7–5 fused tricyclic core. Herein a …

The collective synthesis of pentacyclic stemoamide-type alkaloids is recognized as a
daunting task despite high demand for a comprehensive biological profiling of these natural …

Six Stemona alkaloids were synthesized racemically using stemoamide, obtained via a
cascade cyclization or our reported transannular cyclization of parvistemoamide, as the …

A phytochemical investigation on the alkaloid fractions of Sophora alopecuroides L. led to
the production of 11 undescribed matrine-type alkaloids, sophaloseedlines I–S (1− 11), 12 …

The first asymmetric total syntheses of tuberostemoamide, sessilifoliamide A, and their
epimers have been accomplished via the common intermediate ethylstemoamide. The …

Two approaches allowing access to the tricyclic stemona backbone are presented. Both
approaches rely on a free-radical cyclization reaction as the key step. In the formal synthesis …

A new Lewis acid-assisted Brønsted acid cascade approach for the stereoselective
formation of the tetracyclic Stemona alkaloid skeleton is described in five steps from epoxide …

The extracts of several plants of the Stemonaceae family have long been used in Asian
countries against differentdiseases and for their antiparasitic properties. Significant …

A unified total synthesis of stemoamide-type alkaloids is reported. Our synthetic approach
features the chemoselective convergent assembly of five-membered building blocks via …