In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced
insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different …

The lifespan of Caenorhabditis elegans is regulated by the insulin/insulin-like growth factor
(IGF)-1 receptor homolog DAF-2, which signals through a conserved phosphatidylinositol 3 …

Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2
doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 …

Mutations in daf-2 and age-1 cause a dramatic increase in longevity as well as
developmental arrest at the dauer diapause stage in Caenorhabditis elegans. daf-2 and age …

The insulin/IGF receptor homolog DAF-2 regulates the aging in C. elegans. Decreasing daf-
2 activity causes fertile adults to remain active much longer than normal and to live more …

How are the rates of aging of different tissues coordinated? In Caenorhabditis elegans,
decreasing insulin/IGF-1 signaling extends lifespan by activating the transcription factor DAF …

Genetic and RNA interference (RNAi) screens for life span regulatory genes have revealed
that the daf-2 insulin-like signaling pathway plays a major role in Caenorhabditis elegans …

In Caenorhabditis elegans, the forkhead protein DAF‐16 transduces insulin‐like signals that
regulate larval development and adult lifespan. To identify DAF‐16‐dependent …

Signaling from the DAF-2/insulin receptor to the DAF-16/FOXO transcription factor controls
longevity, metabolism, and development in disparate phyla. To identify genes that mediate …

Background When resources are scant, C. elegans larvae arrest as long-lived dauers under
the control of insulin/IGF-and TGFβ-related signaling pathways. However, critical questions …