Advantages of T-cell-and antibody-based immunotherapy can be combined by grafting
cytotoxic T lymphocytes with chimeric receptors composed of antibody fragments (which …

The application of immunotherapy for the treatment of malignant diseases has attracted
growing interest in recent years. Because T-cell immunity plays a major part in the control of …

The potential of monoclonal antibodies as targeted therapeutics has attracted a huge
amount of interest over recent decades. However, there are still some obstacles to …

Appreciation of the complementary nature of T-cell-and antibody-based immunotherapy
stimulated interest in developing approaches that combine their advantages and minimize …

T cells are the most potent cells of the immune system; however, they fail in the
immunosurveillance of tumors. In previous decades, scientists began studying methods to …

Simple Summary This review highlights the challenges and future directions of cancer
immunotherapies. Monoclonal antibody therapies, adaptive immunotherapies, CAR T cells …

It has been known for some time that mammalian immune systems are capable of
eliminating large tumor burdens. Redirecting the immune response of a patient to an …

Two antigens are better than one | Nature Reviews Cancer Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

A major hurdle to the efficacy of adoptive cell therapy and chimeric antigen receptors T-cell
therapy is the choice of antigen (s) to target. An article in this issue addresses this by …

Targeting of immune cells by bispecific antibodies has proven a powerful tool for the
investigation of cellular cytotoxicity, lymphocyte activation and induction of cytokine …