Hypoxia-preconditioned mesenchymal stem cells ameliorate ischemia/reperfusion-induced lung injury

YY Liu, CH Chiang, SC Hung, CF Chian, CL Tsai… - Plos one, 2017 - journals.plos.org
Background Hypoxia preconditioning has been proven to be an effective method to enhance
the therapeutic action of mesenchymal stem cells (MSCs). However, the beneficial effects of …

Ischemia postconditioning and mesenchymal stem cells engraftment synergistically attenuate ischemia reperfusion-induced lung injury in rats

S Chen, L Chen, X Wu, J Lin, J Fang, X Chen… - Journal of Surgical …, 2012 - Elsevier
BACKGROUND: It has been reported that ischemic postconditioning (IPO) or mesenchymal
stem cell (MSC) engraftment could protect organs from ischemia/reperfusion (I/R) injury. We …

Mesenchymal stem cells protect against neonatal rat hyperoxic lung injury

H Zhang, J Fang, Y Wu, Y Mai, W Lai… - Expert opinion on …, 2013 - Taylor & Francis
Objectives: Bronchopulmonary dysplasia (BPD) is a significant global health problem and
currently lacks effective therapy. We established a neonatal rat model of BPD to investigate …

Hypoxia-preconditioned mesenchymal stem cells prevent renal fibrosis and inflammation in ischemia-reperfusion rats

N Ishiuchi, A Nakashima, S Doi, K Yoshida… - Stem cell research & …, 2020 - Springer
Abstract Background Mesenchymal stem cells (MSCs) have been reported to promote the
regeneration of injured tissue via their paracrine abilities, which are enhanced by hypoxic …

Secretome of mesenchymal stem cells from consecutive hypoxic cultures promotes resolution of lung inflammation by reprogramming anti-inflammatory macrophages

Z Xu, L Lin, Y Fan, C Huselstein, N De Isla… - International Journal of …, 2022 - mdpi.com
The secretome from hypoxia-preconditioned mesenchymal stem cells (MSCs) has been
shown to promote resolution of inflammation and alleviate acute lung injury (ALI) through its …

Hypoxia‐pretreated human MSCs attenuate acute kidney injury through enhanced angiogenic and antioxidative capacities

W Zhang, L Liu, Y Huo, Y Yang… - BioMed research …, 2014 - Wiley Online Library
Hypoxia preconditioning has been confirmed as an effective strategy to enhance the
therapeutic potentials of mesenchymal stem cells (MSCs), such as for myocardial ischemia …

Bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock

S Pati, MH Gerber, TD Menge, KA Wataha, Y Zhao… - PloS one, 2011 - journals.plos.org
Hemorrhagic shock (HS) and trauma is currently the leading cause of death in young adults
worldwide. Morbidity and mortality after HS and trauma is often the result of multi-organ …

Mesenchymal stem cell therapy facilitates donor lung preservation by reducing oxidative damage during ischemia

N Pacienza, D Santa-Cruz, R Malvicini… - Stem Cells …, 2019 - Wiley Online Library
Lung transplantation is a lifesaving therapy for people living with severe, life‐threatening
lung disease. The high mortality rate among patients awaiting transplantation is mainly due …

Human mesenchymal stem cell secretome from bone marrow or adipose-derived tissue sources for treatment of hypoxia-induced pulmonary epithelial injury

N Shologu, M Scully, JG Laffey, D O'Toole - International journal of …, 2018 - mdpi.com
Alveolar epithelial dysfunction induced by hypoxic stress plays a significant role in the
pathological process of lung ischemia-reperfusion injury (IRI). Mesenchymal stem cell …

LincRNA-p21 promotes mesenchymal stem cell migration capacity and survival through hypoxic preconditioning

SS Meng, XP Xu, W Chang, ZH Lu, LL Huang… - Stem cell research & …, 2018 - Springer
Abstract Background Mesenchymal stem cells (MSCs) derived from bone marrow have
potent stabilizing effects for the treatment of acute respiratory distress syndrome (ARDS) …