Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation

BA McLean, CK Wong, JE Campbell… - Endocrine …, 2021 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …

[HTML][HTML] GLP-1 physiology informs the pharmacotherapy of obesity

DJ Drucker - Molecular metabolism, 2022 - Elsevier
Background Glucagon-like peptide-1 receptor agonists (GLP1RA) augment glucose-
dependent insulin release and reduce glucagon secretion and gastric emptying, enabling …

Deciphering metabolic messages from the gut drives therapeutic innovation: the 2014 Banting Lecture

DJ Drucker - Diabetes, 2015 - Am Diabetes Assoc
The Banting Medal for Scientific Achievement is the highest scientific award of the American
Diabetes Association (ADA). Given in memory of Sir Frederick Banting, one of the key …

Minireview: Finding the Sweet Spot: Peripheral Versus Central Glucagon-Like Peptide 1 Action in Feeding and Glucose Homeostasis

DL Williams - Endocrinology, 2009 - academic.oup.com
Glucagon-like peptide 1 (GLP-1) is both a gut-derived hormone and a neurotransmitter
synthesized in the brain. Early reports suggested that GLP-1 acts in the periphery to promote …

[HTML][HTML] Mechanisms of action and therapeutic application of glucagon-like peptide-1

DJ Drucker - Cell metabolism, 2018 - cell.com
Glucagon-like peptide-1 (GLP-1) released from gut enteroendocrine cells controls meal-
related glycemic excursions through augmentation of insulin and inhibition of glucagon …

GLP-1: Molecular mechanisms and outcomes of a complex signaling system

NK Smith, TA Hackett, A Galli, CR Flynn - Neurochemistry international, 2019 - Elsevier
Meal ingestion provokes the release of hormones and transmitters, which in turn regulate
energy homeostasis and feeding behavior. One such hormone, glucagon-like peptide-1 …

Metabolic messengers: glucagon-like peptide 1

FM Gribble, F Reimann - Nature metabolism, 2021 - nature.com
Abstract Glucagon like peptide-1 (GLP-1), a peptide hormone from the intestinal tract, plays
a central role in the coordination of postprandial glucose homeostasis through actions on …

a comparison of glucagon‐like peptides 1 and 2

P Janssen, A Rotondo, F Mulé… - Alimentary pharmacology …, 2013 - Wiley Online Library
Background Recent advancements in understanding the roles and functions of glucagon‐
like peptide 1 (GLP‐1) and 2 (GLP‐2) have provided a basis for targeting these peptides in …

[HTML][HTML] The cardiovascular biology of glucagon-like peptide-1

DJ Drucker - Cell metabolism, 2016 - cell.com
Glucagon-like peptide-1, produced predominantly in enteroendocrine cells, controls glucose
metabolism and energy homeostasis through regulation of islet hormone secretion …

Glucagon-like peptide 1 and appetite

MJ Dailey, TH Moran - Trends in Endocrinology & Metabolism, 2013 - cell.com
Glucagon-like peptide 1 (GLP-1) and GLP-1 analogs have received much recent attention
due to the success of GLP-1 mimetics in treating type II diabetes mellitus (T2DM), but these …