Background Obesity and type 2 diabetes (T2D) are major public health issues worldwide,
and put a significant burden on the healthcare system. Genetic variants, along with …

Abstract Type 2 diabetes (T2D) and obesity are the major public health problems.
Substantial efforts have been made to define loci and variants contributing to the individual …

Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …

Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …

Objective Analysis of the epigenome—the chemical modifications and packaging of the
genome that can influence or indicate its activity—enables molecular insight into cell type …

Metabolic diseases, including type 2 diabetes mellitus (T2DM), are increasing worldwide at
an alarming rate. Epigenetic DNA modifications such as DNA methylation and histone …

Background Obesity is an established risk factor for several common chronic diseases such
as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the …

The increased prevalence of obesity and related comorbidities is a major public health
problem. While genetic factors undoubtedly play a role in determining individual …

Epigenetic marks the genome by DNA methylation, histone modification or non-coding
RNAs. Epigenetic marks instruct cells to respond reversibly to environmental cues and keep …

Background: Recent technological advances in epigenome profiling have led to an
increasing number of studies investigating the role of the epigenome in obesity. There is …