Mutations in presenilin 1 (PS1), which are the major cause of familial Alzheimer's disease
(FAD), are involved in perturbations of cellular Ca2+ homeostasis. Attenuation of …

Alzheimer's disease (AD) is a neurodegenerative disorder that leads to neuron death and
synapse loss in the hippocampus and cortex, with consequent cognitive disability and …

Some forms of familial Alzheimer's disease (FAD) are caused by mutations in presenilins
(PSs), catalytic components of a γ-secretase complex that cleaves target proteins, including …

Presenilins regulate calcium homeostasis in the endoplasmic reticulum, and dysregulation
of intracellular calcium has been implicated in the pathogenesis of Alzheimer disease …

An imbalance in Ca 2+ homeostasis represents an early event in the pathogenesis of
Alzheimer's disease (AD). Presenilin-1 and-2 (PS1 and PS2) mutations, the major cause of …

Alzheimer's disease (AD) is the disease of lost memories. Synaptic loss is a major reason for
memory defects in AD. Signaling pathways involved in memory loss in AD are under intense …

STIM1 is an endoplasmic reticulum protein with a role in Ca 2+ mobilization and signaling.
As a sensor of intraluminal Ca 2+ levels, STIM1 modulates plasma membrane Ca 2+ …

Mutations in the presenilin (PS) genes are linked to the development of early-onset
Alzheimer's disease by a gain-of-function mechanism that alters proteolytic processing of the …

Presenilins are involved in the proteolytic production of Alzheimer's amyloid peptides, but
are also known to regulate Ca2+ homeostasis in various cells types. In the present study, we …

Dysregulation of calcium signaling has been causally implicated in brain aging and
Alzheimer's disease. Mutations in the presenilin genes (PS1, PS2), the leading cause of …